Literature DB >> 2154963

Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat.

K P Gartland1, C T Eason, F W Bonner, J K Nicholson.   

Abstract

The effects of a glutathione depletor, buthionine sulphoximine (BSO) and biliary cannulation on the nephrotoxicity of p-aminophenol (PAP) have been investigated in the F344 rat. Pretreatment with BSO completely protected against the nephrotoxicity of a 50 mg/kg dose of PAP, assessed by clinical chemistry, renal histopathology, and 1H-NMR urinalysis. Biliary cannulation partially protects against nephrotoxicity induced by 100 mg/kg PAP. These data suggest that the nephrotoxicity of PAP may be due in part to the formation of a proximate toxic metabolite in the liver which is excreted in the bile, subsequently reabsorbed and transported via the systemic circulation to the kidney where the toxic effects occur.

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Year:  1990        PMID： 2154963     DOI： 10.1007/BF01973371

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  48 in total

1.  Rapid colorimetric assay of beta-galactosidase and N-acetyl-beta-glucosaminidase in human urine.

Authors:  D Maruhn
Journal:  Clin Chim Acta       Date:  1976-12       Impact factor: 3.786

2.  Proton NMR spectroscopy of bile for monitoring the excretion of endogenous and xenobiotic metabolites: application to para-aminophenol.

Authors:  K P Gartland; C T Eason; K E Wade; F W Bonner; J K Nicholson
Journal:  J Pharm Biomed Anal       Date:  1989       Impact factor: 3.935

3.  Investigations into the biochemical effects of region-specific nephrotoxins.

Authors:  K P Gartland; F W Bonner; J K Nicholson
Journal:  Mol Pharmacol       Date:  1989-02       Impact factor: 4.436

4.  Stimulation of rat hepatic microsomal heme oxygenase by diethyl maleate.

Authors:  R F Burk; M A Correia
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1979-04

5.  Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

Authors:  O W Griffith
Journal:  J Biol Chem       Date:  1982-11-25       Impact factor: 5.157

6.  Early functional and morphological changes in renal tubular necrosis due to p-aminophenol.

Authors:  J M Davis; K R Emslie; R S Sweet; L L Walker; R J Naughton; S L Skinner; J D Tange
Journal:  Kidney Int       Date:  1983-12       Impact factor: 10.612

7.  Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

Authors:  O W Griffith; A Meister
Journal:  J Biol Chem       Date:  1979-08-25       Impact factor: 5.157

8.  Effects of the long-term depletion of reduced glutathione in mice administered L-buthionine-S,R-sulfoximine.

Authors:  J D Sun; S S Ragsdale; J M Benson; R F Henderson
Journal:  Fundam Appl Toxicol       Date:  1985-10

9.  The effects of buthionine sulphoximine (BSO) on glutathione depletion and xenobiotic biotransformation.

Authors:  R Drew; J O Miners
Journal:  Biochem Pharmacol       Date:  1984-10-01       Impact factor: 5.858

10.  Oxidation of p-aminophenol catalyzed by horseradish peroxidase and prostaglandin synthase.

Authors:  P D Josephy; T E Eling; R P Mason
Journal:  Mol Pharmacol       Date:  1983-03       Impact factor: 4.436
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  8 in total

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Authors:  Kazuhisa Miyakawa; Ryan Albee; Lynda G Letzig; Andreas F Lehner; Michael A Scott; John P Buchweitz; Laura P James; Patricia E Ganey; Robert A Roth
Journal:  J Pharmacol Exp Ther       Date:  2015-06-11       Impact factor: 4.030

2.  4-Amino-2-chlorophenol: Comparative in vitro nephrotoxicity and mechanisms of bioactivation.

Authors:  Gary O Rankin; Adam Sweeney; Christopher Racine; Travis Ferguson; Deborah Preston; Dianne K Anestis
Journal:  Chem Biol Interact       Date:  2014-10-19       Impact factor: 5.192

3.  Studies of the biochemical toxicology of uranyl nitrate in the rat.

Authors:  M L Anthony; K P Gartland; C R Beddell; J C Lindon; J K Nicholson
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

4.  Effect of ascorbic acid, acivicin and probenecid on the nephrotoxicity of 4-aminophenol in the Fischer 344 rat.

Authors:  L M Fowler; J R Foster; E A Lock
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

5.  Studies on the effects of L(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) on 4-aminophenol-induced nephrotoxicity in the Fischer 344 rat.

Authors:  M L Anthony; C R Beddell; J C Lindon; J K Nicholson
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

6.  Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors.

Authors:  L M Fowler; J R Foster; E A Lock
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

Review 7.  Reactions of oxidatively activated arylamines with thiols: reaction mechanisms and biologic implications. An overview.

Authors:  P Eyer
Journal:  Environ Health Perspect       Date:  1994-10       Impact factor: 9.031

8.  Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure.

Authors:  Rebecca Dargue; Rabiya Zia; Chungho Lau; Andrew W Nicholls; Theo O Dare; Karla Lee; Rajiv Jalan; Muireann Coen; Ian D Wilson
Journal:  Toxicol Sci       Date:  2020-05-01       Impact factor: 4.849
  8 in total

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