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Literature DB >> 6298570

Reduced [3H]-tetrodotoxin binding in the napts paralytic mutant of Drosophila.

Abstract

The temperature-sensitive paralytic mutant of Drosophila, napts, has been shown to have defects in axonal physiology which suggest that it codes for a component of the voltage-sensitive sodium channel. Ligand binding studies using tritiated tetrodotoxin, a sodium channel antagonist, show a decrease in the apparent number of sodium channels in napts, providing additional support for this hypothesis.

Entities: Chemical Gene Species

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Year: 1982 PMID： 6298570 DOI： 10.1007/bf00384402

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

10 in total

1. A Drosophila mutant with a temperature-sensitive block in nerve conduction.

Authors: C F Wu; B Ganetzky; L Y Jan; Y N Jan; S Benzer
Journal: Proc Natl Acad Sci U S A Date: 1978-08 Impact factor: 11.205

2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors: M M Bradford
Journal: Anal Biochem Date: 1976-05-07 Impact factor: 3.365

3. Selection of variant neuroblastoma clones with missing or altered sodium channels.

Authors: G J West; W A Catterall
Journal: Proc Natl Acad Sci U S A Date: 1979-08 Impact factor: 11.205

4. Temperature-sensitive mutations in Drosophila melanogaster. VII. A mutation (para-ts) causing reversible adult paralysis.

Authors: D T Suzuki; T Grigliatti; R Williamson
Journal: Proc Natl Acad Sci U S A Date: 1971-05 Impact factor: 11.205

5. Genetic alteration of nerve membrane excitability in temperature-sensitive paralytic mutants of Drosophila melanogaster.

Authors: C F Wu; B Ganetzky
Journal: Nature Date: 1980-08-21 Impact factor: 49.962

6. Localization of sodium channels in cultured neural cells.

Authors: W A Catterall
Journal: J Neurosci Date: 1981-07 Impact factor: 6.167

Review 7. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes.

Authors: W A Catterall
Journal: Annu Rev Pharmacol Toxicol Date: 1980 Impact factor: 13.820

8. Saxitoxin binding to sodium channels in head extracts from wild-type and tetrodotoxin-sensitive strains of Drosophila melanogaster.

Authors: J Gitschier; G R Strichartz; L M Hall
Journal: Biochim Biophys Acta Date: 1980-01-25

9. Purification of the tetrodotoxin-binding component associated with the voltage-sensitive sodium channel from Electrophorus electricus electroplax membranes.

Authors: W S Agnew; S R Levinson; J S Brabson; M A Raftery
Journal: Proc Natl Acad Sci U S A Date: 1978-06 Impact factor: 11.205

10. Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster.

Authors: O Siddiqi; S Benzer
Journal: Proc Natl Acad Sci U S A Date: 1976-09 Impact factor: 11.205

10 in total

5 in total

1. Interactions of membrane excitability mutations affecting potassium and sodium currents in the flight and giant fiber escape systems of Drosophila.

Authors: J E Engel; C F Wu
Journal: J Comp Physiol A Date: 1992-08 Impact factor: 1.836

5. Genetic studies of membrane excitability in Drosophila: lethal interaction between two temperature-sensitive paralytic mutations.

Authors: B Ganetzky
Journal: Genetics Date: 1984-12 Impact factor: 4.562