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Literature DB >> 211514

A Drosophila mutant with a temperature-sensitive block in nerve conduction.

C F Wu, B Ganetzky, L Y Jan, Y N Jan, S Benzer.

Abstract

A mutant, napts (no action potential, temperature-sensitive), is described in which axonal conduction fails at high temperature. Synaptic transmission at the larval neuromuscular junction is unimpaired. Larvae and adults are rapidly paralyzed at restrictive temperatures; they recover rapidly when the temperature is decreased. The mutant gene is recessive and is located on the second chromosome at map position 56.

Entities: Gene Species

Mesh：

Year: 1978 PMID： 211514 PMCID： PMC392928 DOI： 10.1073/pnas.75.8.4047

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

12 in total

1. Synaptic transmission reversibly conditioned by single-gene mutation in Drosophila melanogaster.

Authors: K Ikeda; S Ozawa; S Hagiwara
Journal: Nature Date: 1976-02-12 Impact factor: 49.962

2. Two mutations of synaptic transmission in Drosophila.

Authors: Y N Jan; L Y Jan; M J Dennis
Journal: Proc R Soc Lond B Biol Sci Date: 1977-07-28

3. Meiosis in male Drosophila melanogaster I. Isolation and characterization of meiotic mutants affecting second chromosome disjuction.

Authors: R C Gethmann
Journal: Genetics Date: 1974-12 Impact factor: 4.562

4. Development of action potential in larval muscle fibers in Drosophila melanogaster.

Authors: N Suzuki; M Kano
Journal: J Cell Physiol Date: 1977-12 Impact factor: 6.384

5. Temperature-sensitive mutations in Drosophila melanogaster. XIV. A selection of immobile adults.

Authors: T A Grigliatti; L Hall; R Rosenbluth; D T Suzuki
Journal: Mol Gen Genet Date: 1973-01-24

6. Separation of membrane currents using a Paramecium mutant.

Authors: D Oertel; S J Schein; C Kung
Journal: Nature Date: 1977-07-14 Impact factor: 49.962

7. Properties of the larval neuromuscular junction in Drosophila melanogaster.

Authors: L Y Jan; Y N Jan
Journal: J Physiol Date: 1976-10 Impact factor: 5.182

8. L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction.

Authors: L Y Jan; Y N Jan
Journal: J Physiol Date: 1976-10 Impact factor: 5.182

9. Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster.

Authors: O Siddiqi; S Benzer
Journal: Proc Natl Acad Sci U S A Date: 1976-09 Impact factor: 11.205

10. Altered calcium conductance in pawns, behavioural mutants of Paramecium aurelia.

Authors: S J Schein; M V Bennett; G M Katz
Journal: J Exp Biol Date: 1976-12 Impact factor: 3.312

59 in total

1. Where does our behaviour come from?

Authors: P Bateson
Journal: J Biosci Date: 2001-12 Impact factor: 1.826

2. An in vitro method for recording the electrical activity of the isolated heart of the adult Drosophila melanogaster.

Authors: C Papaefthmiou; G Theophilidis
Journal: In Vitro Cell Dev Biol Anim Date: 2001 Jul-Aug Impact factor: 2.416

3. A novel leg-shaking Drosophila mutant defective in a voltage-gated K(+)current and hypersensitive to reactive oxygen species.

Authors: J W Wang; J M Humphreys; J P Phillips; A J Hilliker; C F Wu
Journal: J Neurosci Date: 2000-08-15 Impact factor: 6.167

4. Interactions of membrane excitability mutations affecting potassium and sodium currents in the flight and giant fiber escape systems of Drosophila.

Authors: J E Engel; C F Wu
Journal: J Comp Physiol A Date: 1992-08 Impact factor: 1.836