Literature DB >> 6296853

Human alveolar macrophages produce leukotriene B4.

A O Fels, N A Pawlowski, E B Cramer, T K King, Z A Cohn, W A Scott.   

Abstract

Human alveolar macrophages obtained by bronchoalveolar lavage were labeled overnight with [3H]arachidonic acid. The cells were stimulated with calcium ionophore A23187, and the 20:4 oxygenated metabolites released into the culture medium were identified by reverse-phase HPLC. Leukotriene B4 was the major 20:4 metabolite produced by these cultures. Leukotriene B4 was identified by its reverse-phase HPLC elution time, its UV spectrum, and its chemotactic and chemokinetic activities for neutrophils. In addition, the macrophage- and neutrophil-derived leukotriene B4 free acids and methyl esters were found to have identical HPLC retention times.

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Year:  1982        PMID： 6296853      PMCID： PMC347450          DOI： 10.1073/pnas.79.24.7866

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

Authors:  A Böyum
Journal:  Scand J Clin Lab Invest Suppl       Date:  1968

2.  Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.

Authors:  L Orning; S Hammarström; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

3.  Comparative studies of alanine and alpha-aminoisobutyric acid uptake by freshly isolated rat liver cells.

Authors:  J W Edmondson; L Lumeng; T K Li
Journal:  J Biol Chem       Date:  1979-03-10       Impact factor: 5.157

4.  A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration.

Authors:  W Falk; R H Goodwin; E J Leonard
Journal:  J Immunol Methods       Date:  1980       Impact factor: 2.303

5.  Alveolar macrophage-derived chemotactic factor: kinetics of in vitro production and partial characterization.

Authors:  W W Merrill; G P Naegel; R A Matthay; H Y Reynolds
Journal:  J Clin Invest       Date:  1980-02       Impact factor: 14.808

6.  Extraction of prostaglandins from human blood.

Authors:  W G Unger; I F Stamford; A Bennett
Journal:  Nature       Date:  1971-10-01       Impact factor: 49.962

7.  Defective granulocyte chemotaxis in the Chediak-Higashi syndrome.

Authors:  R A Clark; H R Kimball
Journal:  J Clin Invest       Date:  1971-12       Impact factor: 14.808

8.  Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187.

Authors:  P Borgeat; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

9.  Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.

Authors:  P Borgeat; B Samuelsson
Journal:  J Biol Chem       Date:  1979-04-25       Impact factor: 5.157

10.  Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

Authors:  R C Murphy; S Hammarström; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205
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  46 in total

1.  Relative contribution of leukotriene B4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage.

Authors:  T R Martin; G Raugi; T L Merritt; W R Henderson
Journal:  J Clin Invest       Date:  1987-10       Impact factor: 14.808

2.  Synergistic effects of LTB4 and LTD4 on leukocyte emigration into the guinea pig conjunctiva.

Authors:  C S Spada; D F Woodward; S B Hawley; A L Nieves; L S Williams; B J Feldmann
Journal:  Am J Pathol       Date:  1988-02       Impact factor: 4.307

3.  Transfer of arachidonate from phosphatidylcholine to phosphatidylethanolamine and triacylglycerol in guinea pig alveolar macrophages.

Authors:  J G Nijssen; R S Oosting; F P Nÿkamp; H van den Bosch
Journal:  Lipids       Date:  1986-10       Impact factor: 1.880

4.  Pulmonary alveolar proteinosis: determination of prostaglandins and leukotrienes in lavage fluid.

Authors:  F J Zijlstra; J E Vincent; B van den Berg; H C Hoogsteden; H J Neyens; J J van Dongen
Journal:  Lung       Date:  1987       Impact factor: 2.584

5.  Eicosanoid production in rheumatoid synovitis.

Authors:  E Moilanen; J Alanko; M Nissilä; M Hämäläinen; H Isomäki; H Vapaatalo
Journal:  Agents Actions       Date:  1989-11

6.  Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.

Authors:  T R Martin; B P Pistorese; E Y Chi; R B Goodman; M A Matthay
Journal:  J Clin Invest       Date:  1989-11       Impact factor: 14.808

7.  Human T-lymphocyte subset specificity of the regulatory effects of leukotriene B4.

Authors:  D G Payan; A Missirian-Bastian; E J Goetzl
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

8.  Leukotriene B4, administered via intracerebroventricular injection, attenuates the antigen-induced asthmatic response in sensitized guinea pigs.

Authors:  Yi-Liang Zhu; Shui-Jun Zhang; Yang-Mei Deng; Xin-Wei Dong; Jun-Xia Jiang; Qiang-Min Xie
Journal:  J Neuroinflammation       Date:  2010-02-11       Impact factor: 8.322

Review 9.  Leukotrienes in pulmonary arterial hypertension.

Authors:  Wen Tian; Xinguo Jiang; Yon K Sung; Jin Qian; Ke Yuan; Mark R Nicolls
Journal:  Immunol Res       Date:  2014-05       Impact factor: 2.829

10.  Accumulation of anthracotic particles along lymphatics of the human lung: relevance to "hot spot" formation after inhalation of poorly soluble radionuclides.

Authors:  H Cottier; F Meister; A Zimmermann; R Kraft; A Burkhardt; P Gehr; G Poretti
Journal:  Radiat Environ Biophys       Date:  1987       Impact factor: 1.925
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