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Literature DB >> 6103542

Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.

Abstract

A slow reacting substance produced by rat basophilic leukemia cells, treated with ionophore A23187, was characterized by spectroscopic methods, enzymatic conversions, and chemical degradations as 5-hydroxy-6-S-cysteinylglycyl 7,9,11,14-eicosatetraenoic acid (leukotriene D). gamma-Glutamyltranspeptidase [gamma-glutamyltransferase; (5-glutamyl)-peptide: amino-acid 5-glutamyltransferase, EC 2.3.2.2] converted leukotriene C to a product identical to leukotriene D. This suggests that the stereochemistry of the arachidonyl moiety of leukotrienes C and D is the same [5(S)-6(R)-7,9-trans-11,14-cis]. Leukotriene D induces a faster contraction and, on a molar basis, is more potent than leukotriene C in the isolated guinea pig ileum bioassay.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1980 PMID： 6103542 PMCID： PMC348641 DOI： 10.1073/pnas.77.4.2014

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

28 in total

1. The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock.

Authors: W E BROCKLEHURST
Journal: J Physiol Date: 1960-06 Impact factor: 5.182

2. Liberation of histamine and formation of lysocithin-like substances by cobra venom.

Authors: W Feldberg; C H Kellaway
Journal: J Physiol Date: 1938-11-14 Impact factor: 5.182

3. Release of slow reacting substance (SRS) from rat basophilic leukemia (RBL-1) cells.

Authors: B A Jakschik; A Kulczycki; H H MacDonald; C W Parker
Journal: J Immunol Date: 1977-08 Impact factor: 5.422

4. In vivo and in vitro production of a slow reacting substance in the rat upon treatment with calcium ionophores.

Authors: M K Bach; J R Brashler
Journal: J Immunol Date: 1974-12 Impact factor: 5.422

5. Release of histamine and slow reacting substance of anaphylaxis (SRS-A) by IgE-anti-IgE reactions on monkey mast cells.

Authors: T Ishizaka; K Ishizaka; H Tomioka
Journal: J Immunol Date: 1972-02 Impact factor: 5.422

6. Purification and properties of the slow reacting substance formed in the cat paw perfused with compound 48-80.

Authors: K Strandberg; B Uvnäs
Journal: Acta Physiol Scand Date: 1971-07

7. The capacity of human immunoglobulin E to mediate the release of histamine and slow reacting substance of anaphylaxis (SRS-A) from monkey lung.

Authors: T Ishizaka; K Ishizaka; R P Orange; K F Austen
Journal: J Immunol Date: 1970-02 Impact factor: 5.422

8. Slow-reacting substance of anaphylaxis: purification and characterisation.

Authors: H R Morris; G W Taylor; P J Piper; P Sirois; J R Tippins
Journal: FEBS Lett Date: 1978-03-15 Impact factor: 4.124

9. Release of slow reacting substance of anaphylaxis (SRS-A) from human leukocytes by the calcium ionophore A23187.

Authors: M C Conroy; R P Orange; L M Lichtenstein
Journal: J Immunol Date: 1976-06 Impact factor: 5.422

10. Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids.

Authors: P Borgeat; B Samuelsson
Journal: Proc Natl Acad Sci U S A Date: 1979-07 Impact factor: 11.205

49 in total

1. Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4.

Authors: Ana Lukic; Jie Ji; Helena Idborg; Bengt Samuelsson; Lena Palmberg; Susanne Gabrielsson; Olof Rådmark
Journal: J Lipid Res Date: 2016-07-19 Impact factor: 5.922

2. Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae).

Authors: Marimuthu Govindarajan; Rajamohan Sivakumar
Journal: Parasitol Res Date: 2011-10-20 Impact factor: 2.289

Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.

1. The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock.

2. Liberation of histamine and formation of lysocithin-like substances by cobra venom.

3. Release of slow reacting substance (SRS) from rat basophilic leukemia (RBL-1) cells.

4. In vivo and in vitro production of a slow reacting substance in the rat upon treatment with calcium ionophores.

5. Release of histamine and slow reacting substance of anaphylaxis (SRS-A) by IgE-anti-IgE reactions on monkey mast cells.

6. Purification and properties of the slow reacting substance formed in the cat paw perfused with compound 48-80.

7. The capacity of human immunoglobulin E to mediate the release of histamine and slow reacting substance of anaphylaxis (SRS-A) from monkey lung.

8. Slow-reacting substance of anaphylaxis: purification and characterisation.

9. Release of slow reacting substance of anaphylaxis (SRS-A) from human leukocytes by the calcium ionophore A23187.

10. Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids.

1. Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4.

2. Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae).

3. Effect of leucotrienes C4, D4, prostacyclin and thromboxane A2 on isolated human cerebral arteries.

4. Human lung expresses unique gamma-glutamyl transpeptidase transcripts.

5. Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis.

6. Oxidative inactivation of leukotriene C4 by stimulated human polymorphonuclear leukocytes.

7. Slow reacting substances (leukotrienes): enzymes involved in their biosynthesis.

8. Formation of 11-trans slow reacting substances.

9. Phagocytosis stimulates the release of a slow reacting substance in cultured macrophages.

10. Depletion of glutathione selectively inhibits synthesis of leukotriene C by macrophages.