Literature DB >> 6295110

Effects of nonsteroidal anti-inflammatory drugs on rat gastric mucosal phosphodiesterase activity.

J Silvola, M Kangasaho, O Tokola, H Vapaatalo.   

Abstract

In the present study, the effects of acetylsalicylic acid, diclofenac, ibuprofen, indomethacin, naproxen, phenylbutazone, proquazone, fluproquazone (RF 46-790 N), sulindac (sulfoxide and sulfide forms) and tolfenamic acid were compared on rat gastric mucosal cyclic nucleotide phosphodiesterases (PDEs). Some of the drugs inhibited PDEs effectively, the Ki values being clearly lower than those of theophylline. Mostly the type of inhibition was apparently competitive. Acetylsalicylic acid and ibuprofen were ineffective. No unambiguous correlation between the inhibition of mucosal PDEs and clinically observed gastric irritation was found. However, the inhibition of PDEs may modulate gastric side-effects of NSAIDs.

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Year:  1982        PMID： 6295110     DOI： 10.1007/bf01965936

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  18 in total

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Journal:  Biochem J       Date:  1953-08       Impact factor: 3.857

Review 2.  Review: effect of anti-ulcer drugs on gastric mucous barrier and possible cyclic AMP involvement.

Authors:  M Guslandi
Journal:  Int J Clin Pharmacol Ther Toxicol       Date:  1980-03

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Authors:  K D Rainsford
Journal:  Agents Actions       Date:  1977-07

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Authors:  H Vapaatalo; J Parantainen
Journal:  Med Biol       Date:  1978-08

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Authors:  J Rybicka; K Gibiński
Journal:  Scand J Gastroenterol       Date:  1978       Impact factor: 2.423

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Authors:  T R Russell; W J Thompson; F W Schneider; M M Appleman
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

7.  Cyclic nucleotides and modulation of effector systems of inflammation.

Authors:  M Kaliner; K F Austen
Journal:  Biochem Pharmacol       Date:  1974-02-15       Impact factor: 5.858

8.  Variations in levels of cyclic AMP and GMP in the thymus, spleen and mesenteric lymph node of rats after the induction of adjuvant arthritis.

Authors:  M Tissot; R Bertin; R Portet; J P Giroud
Journal:  Agents Actions       Date:  1980-12

9.  The comparative gastric ulcerogenic activities of non-steroid anti-inflammatory drugs.

Authors:  K D Rainsford
Journal:  Agents Actions       Date:  1977-12

10.  Inhibition of prostaglandin biosynthesis by tolfenamic acid in vitro.

Authors:  I B Lindén; J Parantainen; H Vapaatalo
Journal:  Scand J Rheumatol       Date:  1976       Impact factor: 3.641
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  5 in total

Review 1.  New NSAID targets and derivatives for colorectal cancer chemoprevention.

Authors:  Heather N Tinsley; William E Grizzle; Ashraf Abadi; Adam Keeton; Bing Zhu; Yaguang Xi; Gary A Piazza
Journal:  Recent Results Cancer Res       Date:  2013

2.  Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis.

Authors:  E Seppälä; M Nissilä; H Isomäki; P Nuotio; E Nykänen; O Laitinen; H Vapaatalo
Journal:  Clin Rheumatol       Date:  1985-09       Impact factor: 2.980

3.  TVX 2706--a new phosphodiesterase inhibitor with antiinflammatory action. Biochemical characterization.

Authors:  T Glaser; J Traber
Journal:  Agents Actions       Date:  1984-10

Review 4.  Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states.

Authors:  S P Clissold; R Beresford
Journal:  Drugs       Date:  1987-05       Impact factor: 9.546

5.  Effects of indomethacin, piroxicam and selected prostanoids on gastric acid secretion by the rat isolated gastric mucosa.

Authors:  J J Reeves; R Stables
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739
  5 in total

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