Literature DB >> 345414

Methyl-prostaglandin E2 analogues for healing of gastro-duodenal ulcers.

J Rybicka, K Gibiński.   

Abstract

117 patients were submitted to the randomized double-blind clinical trial. Methylated analogues of prostaglandin E2 administered orally markedly suppressed gastric acid secretion and--in comparison to placebo--accelerated cicatrization of duodenal ulcers, but not of gastric ulcers. The resistance of some ulcers to healing was not dependent on gastric acid secretion.

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Year:  1978        PMID： 345414     DOI： 10.3109/00365527809181742

Source DB:  PubMed          Journal:  Scand J Gastroenterol        ISSN： 0036-5521            Impact factor:   2.423


  9 in total

1.  The pathophysiology of peptic ulcer disease.

Authors:  F P Brooks
Journal:  Dig Dis Sci       Date:  1985-11       Impact factor: 3.199

2.  Effect of 11R, 16, 16-trimethyl prostaglandin E2 on meal-stimulated gastric acid secretion in duodenal ulcer subjects.

Authors:  H J Lenz; S Brozinsky; M A Koss; D L Hogan; M L Scheinbaum; J I Isenberg
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

3.  Effects of nonsteroidal anti-inflammatory drugs on rat gastric mucosal phosphodiesterase activity.

Authors:  J Silvola; M Kangasaho; O Tokola; H Vapaatalo
Journal:  Agents Actions       Date:  1982-10

4.  Diflunisal protects human gastric mucosa against damage by indomethacin.

Authors:  M M Cohen
Journal:  Dig Dis Sci       Date:  1983-12       Impact factor: 3.199

5.  Dose response inhibition in man of meal-stimulated gastric acid secretion by 15(R)-15-methyl prostaglandin E2, given orally.

Authors:  A Robert; G Kane; S B Reele
Journal:  Gut       Date:  1981-09       Impact factor: 23.059

6.  Reduction of aspirin-induced fecal blood loss with low-dose misoprostol tablets in man.

Authors:  M M Cohen; L Clark; L Armstrong; J D'Souza
Journal:  Dig Dis Sci       Date:  1985-07       Impact factor: 3.199

7.  Cytoprotective doses of arbacet with minimal antisecretory properties are not effective in duodenal ulcer healing.

Authors:  D Wengrower; A Fich; E Goldin; R Eliakim; M Ligumsky; D Rachmilewitz
Journal:  Dig Dis Sci       Date:  1987-08       Impact factor: 3.199

8.  Effects of antacids, cimetidine, and 16,16-dimethyl prostaglandin E2 on acute gastric erosions in a spinal rat.

Authors:  H H Sigman; A Gillich
Journal:  Dig Dis Sci       Date:  1982-03       Impact factor: 3.199

9.  Distribution of prostaglandin E2 in gastric and duodenal mucosa: possible role in the pathogenesis of peptic ulcer.

Authors:  S M Park; B C Yoo; H R Lee; H Chung; Y S Lee
Journal:  Korean J Intern Med       Date:  1992-01       Impact factor: 2.884
  9 in total

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