Literature DB >> 6293375

Evaluation of the anti-herpesvirus drug combinations: virazole plus arabinofuranosylhypoxanthine and virazole plus arabinofuranosyladenine.

L B Allen, L K Vanderslice, C M Fingal, F H McCright, E F Harris, P D Cook.   

Abstract

Combinations of Virazole plus arabinofuranosylhypoxanthine (ara-Hx) and Virazole plus arabinofuranosyladenine (ara-A) were investigated in KB or BHK cells infected with types 1 or 2 herpes viruses. Combinations of Virazole and ara-Hx exhibited significant synergy as evaluated graphically (isobolograms) or by fractional inhibitory concentration (FIC) indices. Optimal ratios for the combination were 1:1 to 1:10 for Virazole to ara-Hx. At these ratios, FIC indices in the range of 0.5-0.2 were commonly observed. Combinations of Virazole and ara-A were antagonistic when observed in the presence of pentostatin, an adenosine deaminase inhibitor. In the absence of pentostatin, the minimum inhibitory concentration (MIC) of ara-A and degree of synergy with Virazole were variable.

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Year:  1982        PMID： 6293375     DOI： 10.1016/0166-3542(82)90043-2

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  6 in total

1.  The antiviral activity of the combinations of netropsin derivatives with modified nucleosides and phosphonoacetic acid as estimated in the model of herpesvirus type 1 in a vero cell culture.

Authors:  V L Andronova; S L Grokhovsky; A N Surovaya; G V Gursky; G A Galegov
Journal:  Dokl Biochem Biophys       Date:  2005 Jan-Feb       Impact factor: 0.788

2.  Synergistic anticryptosporidial potential of the combination alpha-1-antitrypsin and paromomycin.

Authors:  J R Forney; S Yang; M C Healey
Journal:  Antimicrob Agents Chemother       Date:  1997-09       Impact factor: 5.191

3.  Inhibitory effects of atropine, protamine, and their combination on hepatitis A virus replication in PLC/PRF/5 cells.

Authors:  E Biziagos; J M Crance; J Passagot; R Deloince
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

4.  Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses.

Authors:  J W Huggins; R K Robins; P G Canonico
Journal:  Antimicrob Agents Chemother       Date:  1984-10       Impact factor: 5.191

5.  Broad-spectrum synergistic antiviral activity of selenazofurin and ribavirin.

Authors:  J J Kirsi; P A McKernan; N J Burns; J A North; B K Murray; R K Robins
Journal:  Antimicrob Agents Chemother       Date:  1984-10       Impact factor: 5.191

6.  Inhibition of vaccinia virus replication by two small interfering RNAs targeting B1R and G7L genes and their synergistic combination with cidofovir.

Authors:  Solenne Vigne; Sophie Duraffour; Graciela Andrei; Robert Snoeck; Daniel Garin; Jean-Marc Crance
Journal:  Antimicrob Agents Chemother       Date:  2009-03-23       Impact factor: 5.191
  6 in total

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