Literature DB >> 9303402

Synergistic anticryptosporidial potential of the combination alpha-1-antitrypsin and paromomycin.

J R Forney1, S Yang, M C Healey.   

Abstract

The combined effect of the serine protease inhibitor alpha-1-antitrypsin (AAT) and the aminoglycoside paromomycin on Cryptosporidium parvum infection in vitro was investigated. AAT and paromomycin were mixed with C. parvum oocysts as either single or combined treatments and used to inoculate epithelial cell cultures. Single- and combined-treatment groups had significantly lower (P < 0.01) parasite numbers than untreated controls. The mean fractional inhibitory concentration indices suggested significant synergistic activity.

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Year:  1997        PMID： 9303402      PMCID： PMC164053          DOI： 10.1128/AAC.41.9.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Paromomycin for the treatment of cryptosporidial diarrhoea in AIDS patients.

Authors:  K Clezy; J Gold; J Blaze; P Jones
Journal:  AIDS       Date:  1991-09       Impact factor: 4.177

2.  Isolation of Cryptosporidium oocysts and sporozoites using discontinuous sucrose and isopycnic Percoll gradients.

Authors:  M J Arrowood; C R Sterling
Journal:  J Parasitol       Date:  1987-04       Impact factor: 1.276

3.  Successful treatment of AIDS-related cryptosporidial sclerosing cholangitis.

Authors:  A A Hamour; A Bonnington; B Hawthorne; E G Wilkins
Journal:  AIDS       Date:  1993-11       Impact factor: 4.177

4.  A method for testing for synergy with any number of agents.

Authors:  M C Berenbaum
Journal:  J Infect Dis       Date:  1978-02       Impact factor: 5.226

5.  Paromomycin inhibits Cryptosporidium infection of a human enterocyte cell line.

Authors:  R J Marshall; T P Flanigan
Journal:  J Infect Dis       Date:  1992-04       Impact factor: 5.226

6.  Protease activity associated with excystation of Cryptosporidium parvum oocysts.

Authors:  J R Forney; S Yang; M C Healey
Journal:  J Parasitol       Date:  1996-12       Impact factor: 1.276

7.  Glycoside antibiotics alone and combined with tetracyclines for prophylaxis of experimental cryptosporidiosis in neonatal BALB/c mice.

Authors:  R Fayer; W Ellis
Journal:  J Parasitol       Date:  1993-08       Impact factor: 1.276

8.  Susceptibility of Giardia lamblia to aminoglycoside protein synthesis inhibitors: correlation with rRNA structure.

Authors:  T D Edlind
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

9.  Paromomycin is effective as prophylaxis for cryptosporidiosis in dairy calves.

Authors:  R Fayer; W Ellis
Journal:  J Parasitol       Date:  1993-10       Impact factor: 1.276

10.  Use of paromomycin for treatment of cryptosporidiosis in patients with AIDS.

Authors:  C J Fichtenbaum; D J Ritchie; W G Powderly
Journal:  Clin Infect Dis       Date:  1993-02       Impact factor: 9.079
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  2 in total

Review 1.  Expanding the clinical indications for α(1)-antitrypsin therapy.

Authors:  Eli C Lewis
Journal:  Mol Med       Date:  2012-09-07       Impact factor: 6.354

2.  Low plasma levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNFalpha), and vascular endothelial growth factor (VEGF) in patients with alpha1-antitrypsin deficiency-related fibromyalgia.

Authors:  Ignacio Blanco; Sabina Janciauskiene; Izabela Nita; Enrique Fernández-Bustillo; Victoriano Cárcaba; César Gallo; Marlene Alvarez-Rico; Frederick de Serres; Nana Béridze
Journal:  Clin Rheumatol       Date:  2009-11-19       Impact factor: 2.980
  2 in total

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