Literature DB >> 6290784

Biology of disease: free radicals and tissue injury.

B A Freeman, J D Crapo.   

Abstract

A free radical is any molecule that has an odd number of electrons. Free radicals, which can occur in both organic (i.e., quinones) and inorganic molecules (i.e., O(2)), are highly reactive and, therefore, transient. Free radicals are generated in vivo as by products of normal metabolism. They are also produced when an organism is exposed to ionizing radiation, to drugs capable of redox cycling, or to xenobiotics that can form free radical metabolites in situ. Cellular targets at risk from free radical damage depend on the nature of the radical and its site of generation. In this review we survey cellular sources of free radicals and the reactions they can undergo and discuss cellular defenses and adaptive mechanisms.

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Year:  1982        PMID： 6290784

Source DB:  PubMed          Journal:  Lab Invest        ISSN： 0023-6837            Impact factor:   5.662


  475 in total

1.  Protective effect of secoisolariciresinol diglucoside against streptozotocin-induced diabetes and its mechanism.

Authors:  K Prasad; S V Mantha; A D Muir; N D Westcott
Journal:  Mol Cell Biochem       Date:  2000-03       Impact factor: 3.396

2.  Surfactant protein A mediates mycoplasmacidal activity of alveolar macrophages by production of peroxynitrite.

Authors:  J Hickman-Davis; J Gibbs-Erwin; J R Lindsey; S Matalon
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

3.  Oral repletion of iron induces free radical mediated alterations in the gastrointestinal tract of rat.

Authors:  K Srigiridhar; K M Nair; R Subramanian; L Singotamu
Journal:  Mol Cell Biochem       Date:  2001-03       Impact factor: 3.396

4.  Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase.

Authors:  Shen-Ting Zhao; Xiao-Tian Huang; Ce Zhang; Ya Ke
Journal:  Neurochem Res       Date:  2011-09-21       Impact factor: 3.996

5.  Perfusion-Perls and -Turnbull methods supplemented by DAB intensification for nonheme iron histochemistry: demonstration of the superior sensitivity of the methods in the liver, spleen, and stomach of the rat.

Authors:  Reiko Meguro; Yoshiya Asano; Hiroyasu Iwatsuki; Kazuhiko Shoumura
Journal:  Histochem Cell Biol       Date:  2003-06-12       Impact factor: 4.304

6.  The immunocytochemical localization of superoxide dismutase in the enterocytes of the avian intestine: the effect of vitamin D3.

Authors:  W L Davis; J L Matthews; K Shibata; M Kipnis; G R Farmer; E Cortinas; J C Meiyr; D B Goodman
Journal:  Histochem J       Date:  1989-04

7.  Uric acid as radical scavenger and antioxidant in the heart.

Authors:  B F Becker; N Reinholz; T Ozçelik; B Leipert; E Gerlach
Journal:  Pflugers Arch       Date:  1989-11       Impact factor: 3.657

8.  Role of membrane-associated Ca+ dependent matrix metalloprotease-2 in the oxidant activation of Ca2+Atpase by tertiary butylhydroperoxide.

Authors:  Sudip Das; Tapati Chakraborti; Malay Mandal; Amritlal Mandal; Sajal Chakraborti
Journal:  Mol Cell Biochem       Date:  2002-08       Impact factor: 3.396

Review 9.  Molecular mechanisms of Cr(VI)-induced carcinogenesis.

Authors:  Min Ding; Xianglin Shi
Journal:  Mol Cell Biochem       Date:  2002 May-Jun       Impact factor: 3.396

10.  GSH-dependent inhibition of lipid peroxidation: properties of a potent cytosolic system which protects cell membranes.

Authors:  D D Gibson; J Hawrylko; P B McCay
Journal:  Lipids       Date:  1985-10       Impact factor: 1.880
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