| Literature DB >> 6290243 |
J L Boyer, C Posadas, J A García-Sáinz.
Abstract
Administration of pertussis vaccine to rats markedly diminished the sensitivity of their vascular alpha 2-adrenoceptors as evidenced by shifts to the right and decreased maximal pressor responses to clonidine and azepexole in pithed rats. No effect was observed on the sensitivity of alpha 1-adrenoceptors as evidenced by the dose-response curve to methoxamine. A slight persistent tachycardia was also produced by the vaccine. A model to explain the effects of the vaccine on the vascular system of the rat is proposed.Entities:
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Year: 1982 PMID： 6290243 DOI： 10.1016/0014-2999(82)90295-3
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432