Literature DB >> 6289163

New implantable continuous administration and bolus dose intracarotid drug delivery system for the treatment of malignant gliomas.

T W Phillips, W F Chandler, G W Kindt, W D Ensminger, H S Greenberg, J F Seeger, K M Doan, J W Gyves.   

Abstract

A totally implantable system for the continuous and bolus delivery of intra-arterial chemotherapeutic agents to patients with malignant gliomas is described. The system utilizes an Infusaid pump (Infusaid Corp., Sharon, Massachusetts), which discharges the drug directly into the internal carotid artery and is percutaneously refillable. This system has been utilized experimentally in primates and in the treatment of six patients with malignant gliomas. It seems that this system can be utilized safely as an experimental technique in the treatment of malignant gliomas.

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Year:  1982        PMID： 6289163     DOI： 10.1227/00006123-198208000-00001

Source DB:  PubMed          Journal:  Neurosurgery        ISSN： 0148-396X            Impact factor:   4.654


  12 in total

Review 1.  Neuro-oncology index and review (adult primary brain tumors). Radiotherapy, chemotherapy, immunotherapy, photodynamic therapy.

Authors:  M S Mahaley
Journal:  J Neurooncol       Date:  1991-10       Impact factor: 4.130

Review 2.  Implantable pumps for drug delivery to the brain.

Authors:  S Bakhshi; R B North
Journal:  J Neurooncol       Date:  1995-11       Impact factor: 4.130

3.  Rationally designed pharmacogenomic treatment using concurrent capecitabine and radiotherapy for glioblastoma; gene expression profiles associated with outcome.

Authors:  Jessica M Grunda; John Fiveash; Cheryl A Palmer; Alan Cantor; Hassan M Fathallah-Shaykh; L Burt Nabors; Martin R Johnson
Journal:  Clin Cancer Res       Date:  2010-05-11       Impact factor: 12.531

4.  Intra-arterial BCNU in the treatment of metastatic brain tumors.

Authors:  T L Cascino; T N Byrne; M D Deck; J B Posner
Journal:  J Neurooncol       Date:  1983       Impact factor: 4.130

5.  Capillary gas chromatography and thermionic N-P-specific detection of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in stability and pharmacokinetic studies.

Authors:  A El-Yazigi; C R Martin
Journal:  Pharm Res       Date:  1988-04       Impact factor: 4.200

6.  Complications associated with intra-arterial BCNU administered in combination with vincristine and procarbazine for the treatment of malignant brain tumors.

Authors:  A M Bremer; E Kleriga; T Q Nguyen; R Balsys; H M Northup; N Gonzalez; P Duarte; R I Miller
Journal:  J Neurooncol       Date:  1984       Impact factor: 4.130

7.  Delivery of a novel nitrosourea, MCNU, to the brain tissue in glioma-bearing rats. Intracarotid versus intravenous infusion.

Authors:  A Hodozuka; K Sako; H Nakai; M Tomabechi; N Suzuki; Y Yonemasu
Journal:  J Neurooncol       Date:  1993-01       Impact factor: 4.130

8.  Phase I clinical trial of intracarotid bis-chloroethylnitrosourea (BCNU) and 2' dioxy-5-fluorouridine (FUDR) in malignant astrocytomas.

Authors:  T I Mughal; L M Glode; T J Braun; W Klingensmith; J M Geier; G W Kindt
Journal:  J Neurooncol       Date:  1986       Impact factor: 4.130

9.  Central neurotoxicity following intracarotid BCNU chemotherapy for malignant gliomas.

Authors:  M S Mahaley; R A Whaley; M Blue; L Bertsch
Journal:  J Neurooncol       Date:  1986       Impact factor: 4.130

10.  Intra-arterial 5-bromo-2-deoxyuridine (BUdR) radiosensitization with external beam radiation in rhesus monkeys: toxicity study.

Authors:  H S Greenberg; W F Chandler; R F Diaz; D R Averill; S S Gebarski; A S Lichter; W D Ensminger
Journal:  J Neurooncol       Date:  1988-12       Impact factor: 4.130
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