Literature DB >> 6288418

Xanthine derivatives as adenosine receptor antagonists.

B B Fredholm, C G Persson.   

Abstract

The potency of a series of xanthine derivatives as adenosine antagonists was studied in fat cells (A1-receptors) and hippocampal slices (A2-receptors) and on L-[3H]phenylisopropyladenosine (PIA) binding in membranes from rat cortex. The order of potency in all three tests systems was: diethyl-8-phenyl-theophylline greater than 8-phenyltheophylline greater than 8-p-sulfophenyltheophylline greater than verrophylline greater than isobutylmethylxanthine greater than theophylline caffeine greater than theobromine. Enprofylline was about 20 times more potent in the hippocampus system than in the other two systems.

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Year:  1982        PMID： 6288418     DOI： 10.1016/0014-2999(82)90359-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  44 in total

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5.  A novel 8-phenyl-substituted xanthine derivative is a selective antagonist at adenosine A1-receptors in vivo.

Authors:  K A Jakobson; K L Kirk; J W Daly; B Jonzon; Y O Li; B B Fredholm
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7.  Increase in plasma free fatty acids and natriuresis by xanthines may reflect adenosine antagonism.

Authors:  K E Andersson; N Johannesson; B Karlberg; C G Persson
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

Review 8.  Theophylline poisoning. Pharmacological considerations and clinical management.

Authors:  P Gaudreault; J Guay
Journal:  Med Toxicol       Date:  1986 May-Jun

9.  Dual effect of (-)-N6-phenylisopropyl adenosine on guinea-pig trachea.

Authors:  L Caparrotta; F Cillo; G Fassina; R M Gaion
Journal:  Br J Pharmacol       Date:  1984-09       Impact factor: 8.739

10.  Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine.

Authors:  Jiang-Ning Yang; Jiang-Fan Chen; Bertil B Fredholm
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-02-13       Impact factor: 4.733
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