Literature DB >> 6287573

Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus.

N Tsuchida, T Ryder, E Ohtsubo.   

Abstract

The transforming protein of Kirsten murine sarcoma virus (Ki-MuSV) is a virally encoded 21-kilodalton protein called p21 kis. The sequences encoding p21 kis were genetically localized to a 1.3-kilobase segment near the 5' end of the viral genome by assaying the capacity of a series of defined deletion mutants of molecularly cloned Ki-MuSV DNA to induce focal transformation of mouse cells. Nucleotide sequencing of a portion of this region has led to the identification of an open reading frame of 567 nucleotides coding for p21 kis protein.

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Year:  1982        PMID： 6287573     DOI： 10.1126/science.6287573

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  70 in total

1.  Conformational effects of amino acid substitutions at positions 10, 12, and 13 in the P21 protein.

Authors:  P W Brandt-Rauf; M R Pincus; R P Carty; J Lubowsky; M Avitable; H F Kung; J Maizel
Journal:  J Protein Chem       Date:  1989-02

2.  Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation.

Authors:  R Foster; K Q Hu; Y Lu; K M Nolan; J Thissen; J Settleman
Journal:  Mol Cell Biol       Date:  1996-06       Impact factor: 4.272

3.  Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies.

Authors:  Andrew M Waters; Irem Ozkan-Dagliyan; Angelina V Vaseva; Nicole Fer; Leslie A Strathern; G Aaron Hobbs; Basile Tessier-Cloutier; William K Gillette; Rachel Bagni; Gordon R Whiteley; James L Hartley; Frank McCormick; Adrienne D Cox; Peter J Houghton; David G Huntsman; Mark R Philips; Channing J Der
Journal:  Sci Signal       Date:  2017-09-26       Impact factor: 8.192

4.  Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product.

Authors:  M O Weeks; G L Hager; R Lowe; E M Scolnick
Journal:  J Virol       Date:  1985-05       Impact factor: 5.103

5.  Analysis of viral and somatic activations of the cHa-ras gene.

Authors:  C J Tabin; R A Weinberg
Journal:  J Virol       Date:  1985-01       Impact factor: 5.103

6.  Nucleotide sequence analysis of the BALB/c murine sarcoma virus transforming gene.

Authors:  E P Reddy; D Lipman; P R Andersen; S R Tronick; S A Aaronson
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

7.  Activation of Ha-ras p21 by substitution, deletion, and insertion mutations.

Authors:  R G Chipperfield; S S Jones; K M Lo; R A Weinberg
Journal:  Mol Cell Biol       Date:  1985-08       Impact factor: 4.272

8.  ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins.

Authors:  D C Fry; S A Kuby; A S Mildvan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

9.  Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

Authors:  H Nakano; F Yamamoto; C Neville; D Evans; T Mizuno; M Perucho
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

10.  Regional chromosomal localization of N-ras, K-ras-1, K-ras-2 and myb oncogenes in human cells.

Authors:  O W McBride; D C Swan; S R Tronick; R Gol; D Klimanis; D E Moore; S A Aaronson
Journal:  Nucleic Acids Res       Date:  1983-12-10       Impact factor: 16.971
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