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Literature DB >> 6287456

Proteins specified by avian erythroblastosis virus: coding region localization and identification of a previously undetected erb-B polypeptide.

Abstract

Avian erythroblastosis virus (AEV) induces erythroblastosis and sarcomas in chickens. Two domains within the viral genome, erb-A and erb-B, have been implicated in AEV-mediated oncogenesis. By use of hybridization-arrested translations and hybridization-selections of mRNA, we have mapped on the viral genome the polypeptides specified by the erb domains. The results of hybridization-arrest with DNA representing the spliced 5' leader region of the AEV mRNA suggested that the authentic product of the erb-B domain was a 61,000 molecular weight protein, not a 41,000 molecular weight polypeptide previously identified.

Entities: Disease Species

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Year: 1982 PMID： 6287456 PMCID： PMC346555 DOI： 10.1073/pnas.79.13.3958

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

25 in total

1. Avian erythroblastosis virus: transformation-specific sequences form a contiguous segment of 3.25 kb located in the middle of the 6-kb genome.

Authors: M M Lai; S S Hu; P K Vogt
Journal: Virology Date: 1979-09 Impact factor: 3.616

2. Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation.

Authors: M Roussel; S Saule; C Lagrou; C Rommens; H Beug; T Graf; D Stehelin
Journal: Nature Date: 1979-10-11 Impact factor: 49.962

3. Cell-free translation of avian sarcoma virus RNA: suppression of the gag termination codon does not augment synthesis of the joint gag/pol product.

Authors: S R Weiss; P B Hackett; H Oppermann; A Ullrich; L Levintow; J M Bishop
Journal: Cell Date: 1978-10 Impact factor: 41.582

4. Defectiveness of avian erythroblastosis virus: synthesis of a 75K gag-related protein.

Authors: M J Hayman; B Royer-Pokora; T Graf
Journal: Virology Date: 1979-01-15 Impact factor: 3.616

5. Cell-free translation of avian erythroblastosis virus RNA yields two specific and distinct proteins with molecular weights of 75,000 and 40,000.

Authors: M M Lai; J C Neil; P K Vogt
Journal: Virology Date: 1980-01-30 Impact factor: 3.616

6. Quantitative analysis of specific labelled RNA'S using DNA covalently linked to diazobenzyloxymethyl-paper.

Authors: G R Stark; J G Williams
Journal: Nucleic Acids Res Date: 1979-01 Impact factor: 16.971

7. In vitro translation of avian erythroblastosis virus RNA: identification of two major polypeptides.

Authors: M Yoshida; K Toyoshima
Journal: Virology Date: 1980-01-30 Impact factor: 3.616

8. Proposal for naming host cell-derived inserts in retrovirus genomes.

Authors: J M Coffin; H E Varmus; J M Bishop; M Essex; W D Hardy; G S Martin; N E Rosenberg; E M Scolnick; R A Weinberg; P K Vogt
Journal: J Virol Date: 1981-12 Impact factor: 5.103

9. Structure and specific sequences of avian erythroblastosis virus RNA: evidence for multiple classes of transforming genes among avian tumor viruses.

Authors: K Bister; P H Duesberg
Journal: Proc Natl Acad Sci U S A Date: 1979-10 Impact factor: 11.205

10. gag-Related polypeptides encoded by replication-defective avian oncoviruses.

Authors: C W Rettenmier; S M Anderson; M W Riemen; H Hanafusa
Journal: J Virol Date: 1979-12 Impact factor: 5.103

16 in total

1. Dissecting the activating mutations in v-erbB of avian erythroblastosis virus strain R.

Authors: H K Shu; R J Pelley; H J Kung
Journal: J Virol Date: 1991-11 Impact factor: 5.103

2. The avian erythroblastosis virus erbA oncogene encodes a DNA-binding protein exhibiting distinct nuclear and cytoplasmic subcellular localizations.

Authors: P Boucher; A Koning; M L Privalsky
Journal: J Virol Date: 1988-02 Impact factor: 5.103

3. A single amino acid substitution in v-erbB confers a thermolabile phenotype to ts167 avian erythroblastosis virus-transformed erythroid cells.

Authors: O R Choi; C Trainor; T Graf; H Beug; J D Engel
Journal: Mol Cell Biol Date: 1986-05 Impact factor: 4.272

4. The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases.

Authors: M L Privalsky; R Ralston; J M Bishop
Journal: Proc Natl Acad Sci U S A Date: 1984-02 Impact factor: 11.205

5. Induction of angiosarcoma by a c-erbB transducing virus.

Authors: S E Tracy; B A Woda; H L Robinson
Journal: J Virol Date: 1985-05 Impact factor: 5.103

6. Structural domains of the avian erythroblastosis virus erbB protein required for fibroblast transformation: dissection by in-frame insertional mutagenesis.

Authors: M Ng; M L Privalsky
Journal: J Virol Date: 1986-05 Impact factor: 5.103

7. Mammalian cell transformation by a murine retrovirus vector containing the avian erythroblastosis virus erbB gene.

Authors: A Gazit; J H Pierce; M H Kraus; P P Di Fiore; C Y Pennington; S A Aaronson
Journal: J Virol Date: 1986-10 Impact factor: 5.103

8. A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.

Authors: A I Dayton; J R Selden; G Laws; D J Dorney; J Finan; P Tripputi; B S Emanuel; G Rovera; P C Nowell; C M Croce
Journal: Proc Natl Acad Sci U S A Date: 1984-07 Impact factor: 11.205

9. An EcoRI restriction fragment length polymorphism (RFLP) in the human c-erb A locus.

Authors: D Mathieu-Mahul; D Q Xu; S Saule; R Lidereau; F Galibert; R Berger; M Mauchauffé; C J Larsen
Journal: Hum Genet Date: 1985 Impact factor: 4.132

10. Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.

Authors: M Kozak
Journal: Proc Natl Acad Sci U S A Date: 1986-05 Impact factor: 11.205