Literature DB >> 6285471

Cellular transforming genes.

G M Cooper.   

Abstract

Cellular genes potentially capable of inducing oncogenic transformation have been identified by homology to the transforming genes of retroviruses and by the biological activity of cellular DNA's in transfection assays. DNA's of various tumors induce transformation with high efficiencies, indicating that oncogenesis can involve dominant genetic alterations resulting in activation of cellular transforming genes. The identification and characterization of cellular transforming genes and their possible involvement in naturally occurring cancers, is discussed.

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Year:  1982        PMID： 6285471     DOI： 10.1126/science.6285471

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  119 in total

Review 1.  Demystified ... oncogenes.

Authors:  Y L Wallis; F Macdonald
Journal:  Mol Pathol       Date:  1999-04

2.  Induction of urokinase activity and malignant phenotype in bladder carcinoma cells after transfection of the activated Ha-ras oncogene.

Authors:  G Brunner; J Pohl; L J Erkell; A Radler-Pohl; V Schirrmacher
Journal:  J Cancer Res Clin Oncol       Date:  1989       Impact factor: 4.553

3.  Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

Authors:  P L Felgner; T R Gadek; M Holm; R Roman; H W Chan; M Wenz; J P Northrop; G M Ringold; M Danielsen
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

4.  "Hopeful monsters," transposons, and Metazoan radiation.

Authors:  D H Erwin; J W Valentine
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

Review 5.  Quantitative genetic analysis of tumor progression.

Authors:  V Ling; A F Chambers; J F Harris; R P Hill
Journal:  Cancer Metastasis Rev       Date:  1985       Impact factor: 9.264

6.  O6-Methylguanine repair of methylated DNA in vitro: cell cycle-dependence of rat liver methyltransferase activity.

Authors:  C Schuster; G Rode; H M Rabes
Journal:  J Cancer Res Clin Oncol       Date:  1985       Impact factor: 4.553

7.  Establishment and characterization of cell lines from the Walker carcinoma 256 able to grow in suspension culture and deficient in thymidine kinase.

Authors:  F Arvelo; A Yabrudi; M E Delgado; N González-Cadavid
Journal:  In Vitro       Date:  1984-07

Review 8.  Generation of phenotypic diversity and progression in metastatic tumor cells.

Authors:  G L Nicolson
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

Review 9.  Human oncogenes.

Authors:  K Willecke; R Schäfer
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

10.  Human c-fms proto-oncogene: comparative analysis with an abnormal allele.

Authors:  J S Verbeek; A J Roebroek; A M van den Ouweland; H P Bloemers; W J Van de Ven
Journal:  Mol Cell Biol       Date:  1985-02       Impact factor: 4.272
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