Literature DB >> 6284988

Genetic analysis of murine hepatitis virus strain JHM.

J L Leibowitz, J R DeVries, M V Haspel.   

Abstract

We performed a genetic analysis of 37 temperature-sensitive mutants of murine hepatitis virus strain JHM. Of our mutants, 32 did not induce murine hepatitis virus-specific RNA synthesis in infected cells at the restrictive temperature, 39 degrees C. By complementation testing we have identified at least seven nonoverlapping complementation groups. Six of the genes identified in this way are required for murine hepatitis virus-specific RNA synthesis. The seventh complementation group is made up of five mutants which induced virus-specific RNA synthesis at 39 degrees C.

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Year:  1982        PMID： 6284988      PMCID： PMC256945     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  12 in total

1.  Genomic RNA of the murine coronavirus JHM.

Authors:  H Wege; A Müller; V ter Meulen
Journal:  J Gen Virol       Date:  1978-11       Impact factor: 3.891

2.  Enhanced growth of a murine coronavirus in transformed mouse cells.

Authors:  L S Sturman; K K Takemoto
Journal:  Infect Immun       Date:  1972-10       Impact factor: 3.441

3.  Proposal for a uniform nomenclature for simian virus 40 mutants.

Authors:  J A Robb; P Tegtmeyer; R G Martin; S Kit
Journal:  J Virol       Date:  1972-03       Impact factor: 5.103

4.  Isolation and preliminary genetic and biochemical characterization of temperature-sensitive mutants of reovirus.

Authors:  B N Fields; W K Joklik
Journal:  Virology       Date:  1969-03       Impact factor: 3.616

5.  Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

Authors:  G K McMaster; G G Carmichael
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

6.  Pathogenic murine coronaviruses. II. Characterization of virus-specific proteins of murine coronaviruses JHMV and A59V.

Authors:  C W Bond; J L Leibowitz; J A Robb
Journal:  Virology       Date:  1979-04-30       Impact factor: 3.616

7.  Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination.

Authors:  M V Haspel; P W Lampert; M B Oldstone
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

8.  Pathogenic murine coronaviruses. III. Biological and biochemical characterization of temperature-sensitive mutants of JHMV.

Authors:  J A Robb; C W Bond; J L Leibowitz
Journal:  Virology       Date:  1979-04-30       Impact factor: 3.616

9.  Isolation and identification of virus-specific mRNAs in cells infected with mouse hepatitis virus (MHV-A59).

Authors:  W J Spaan; P J Rottier; M C Horzinek; B A van der Zeijst
Journal:  Virology       Date:  1981-01-30       Impact factor: 3.616

10.  Pathogenic murine coronaviruses. I. Characterization of biological behavior in vitro and virus-specific intracellular RNA of strongly neurotropic JHMV and weakly neurotropic A59V viruses.

Authors:  J A Robb; C W Bond
Journal:  Virology       Date:  1979-04-30       Impact factor: 3.616
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  24 in total

1.  Identification of a domain required for autoproteolytic cleavage of murine coronavirus gene A polyprotein.

Authors:  S C Baker; C K Shieh; L H Soe; M F Chang; D M Vannier; M M Lai
Journal:  J Virol       Date:  1989-09       Impact factor: 5.103

2.  Recombination between nonsegmented RNA genomes of murine coronaviruses.

Authors:  M M Lai; R S Baric; S Makino; J G Keck; J Egbert; J L Leibowitz; S A Stohlman
Journal:  J Virol       Date:  1985-11       Impact factor: 5.103

3.  In vitro replication of mouse hepatitis virus strain A59.

Authors:  S R Compton; D B Rogers; K V Holmes; D Fertsch; J Remenick; J J McGowan
Journal:  J Virol       Date:  1987-06       Impact factor: 5.103

4.  Identification and stability of a 30-kDa nonstructural protein encoded by mRNA 2 of mouse hepatitis virus in infected cells.

Authors:  P J Bredenbeek; A F Noten; M C Horzinek; W J Spaan
Journal:  Virology       Date:  1990-03       Impact factor: 3.616

5.  The primary structure and expression of the second open reading frame of the polymerase gene of the coronavirus MHV-A59; a highly conserved polymerase is expressed by an efficient ribosomal frameshifting mechanism.

Authors:  P J Bredenbeek; C J Pachuk; A F Noten; J Charité; W Luytjes; S R Weiss; W J Spaan
Journal:  Nucleic Acids Res       Date:  1990-04-11       Impact factor: 16.971

6.  Genetics of mouse hepatitis virus transcription: evidence that subgenomic negative strands are functional templates.

Authors:  M C Schaad; R S Baric
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

7.  Coronavirus multiplication: locations of genes for virion proteins on the avian infectious bronchitis virus genome.

Authors:  D F Stern; B M Sefton
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

8.  Map locations of mouse hepatitis virus temperature-sensitive mutants: confirmation of variable rates of recombination.

Authors:  K Fu; R S Baric
Journal:  J Virol       Date:  1994-11       Impact factor: 5.103

9.  Characterization of a human coronavirus (strain 229E) 3C-like proteinase activity.

Authors:  J Ziebuhr; J Herold; S G Siddell
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103

10.  Identification of novel functional regions within the spike glycoprotein of MHV-A59 based on a bioinformatics approach.

Authors:  Gili Kaufman; Pinghua Liu; Julian L Leibowitz
Journal:  Virus Res       Date:  2014-06-05       Impact factor: 3.303
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