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Literature DB >> 6282935

Human platelets contain gelsolin. A regulator of actin filament length.

Abstract

Morphologic and biochemical studies suggest that actin in human platelets polymerizes in response to various stimuli and that shortening of actin filaments can be regulated by calcium. We report that human platelets contain gelsolin, a protein of Mr 91,000 that binds reversibly to actin in the presence of calcium. Platelet gelsolin exhibits immunologic crossreactivity with rabbit macrophage gelsolin and shortens actin filaments as demonstrated by viscosity measurements and gel point determinations. Gelsolin is active in micromolar calcium concentrations and its effects upon actin filaments are reversible. Gelsolin may be a dynamic regulator of actin filament length in the human platelet.

Entities: Chemical Gene Species

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Year: 1982 PMID： 6282935 PMCID： PMC370211 DOI： 10.1172/jci110578

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

15 in total

1. Reorganization of actin in platelets stimulated by thrombin as measured by the DNase I inhibition assay.

Authors: L Carlsson; F Markey; I Blikstad; T Persson; U Lindberg
Journal: Proc Natl Acad Sci U S A Date: 1979-12 Impact factor: 11.205

2. Ca2+-dependent protease in human platelets. Specific cleavage of platelet polypeptides in the presence of added Ca2+.

Authors: D R Phillips; M Jakábová
Journal: J Biol Chem Date: 1977-08-25 Impact factor: 5.157

3. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors: H Towbin; T Staehelin; J Gordon
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

Review 4. Platelet contractile proteins.

Authors: R S Adelstein; T D Pollard
Journal: Prog Hemost Thromb Date: 1978

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Authors: J A Spudich; S Watt
Journal: J Biol Chem Date: 1971-08-10 Impact factor: 5.157

6. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

7. Ca2+ control of actin gelation. Interaction of gelsolin with actin filaments and regulation of actin gelation.

Authors: H L Yin; K S Zaner; T P Stossel
Journal: J Biol Chem Date: 1980-10-10 Impact factor: 5.157

8. Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner.

Authors: A Bretscher; K Weber
Journal: Cell Date: 1980-07 Impact factor: 41.582

9. Characterization of platelet extracts before and after stimulation with respect to the possible role of profilactin as microfilament precursor.

Authors: F Markey; T Persson; U Lindberg
Journal: Cell Date: 1981-01 Impact factor: 41.582

10. Cytoskeleton of human platelets at rest and after spreading.

Authors: V T Nachmias
Journal: J Cell Biol Date: 1980-09 Impact factor: 10.539

13 in total

1. Aggregation-related association of lipid with the cytoskeleton of rabbit and human platelets prelabeled with [3H]palmitic acid. Similar effects of adenosine diphosphate- and thrombin-induced aggregation.

Authors: A Livne; M A Packham; M A Guccione; J F Mustard
Journal: J Clin Invest Date: 1988-02 Impact factor: 14.808

2. Redistribution of membrane-bound and cytosolic action in rabbit polymorphonuclear leucocytes during phagocytosis.

Authors: D I Stewart; N Crawford
Journal: Biochem J Date: 1985-02-01 Impact factor: 3.857

3. Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk.

Authors: Yongyue Wei; Zhaoxi Wang; Li Su; Feng Chen; Paula Tejera; Ednan K Bajwa; Mark M Wurfel; Xihong Lin; David C Christiani
Journal: Chest Date: 2015-03 Impact factor: 9.410

4. Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib.

Authors: J E Fox
Journal: J Clin Invest Date: 1985-10 Impact factor: 14.808

5. Role of gelsolin interaction with actin in regulation and creation of actin nuclei in chemotactic peptide activated polymorphonuclear neutrophils.

Authors: J D Deaton; T Guerrero; T H Howard
Journal: Mol Biol Cell Date: 1992-12 Impact factor: 4.138