Literature DB >> 6282594

Rapid miniaturized chromatography for Tc-99m IDA agents: comparison with gel chromatography.

A M Zimmer, W Majewski, S M Spies.   

Abstract

Miniaturized chromatography systems for determining free pertechnetate and hydrolyzed reduced 99mTc levels in commercial 99mTc-labeled iminodiacetate (IDA) hepatobiliary radiopharmaceuticals were evaluated and the results compared with gel chromatography column scanning (GCS). Commercial IDA agents were evaluated including 2,6-dimethyl IDA, p-isopropyl IDA, p-butyl IDA, and 2,6-diisopropyl IDA. Of all the chromatography systems evaluated, only Gelman ITLC-SA with 20% NaCl and Gelman ITLC-SG with distilled water correlated with GCS in evaluating free pertechnetate and hydrolyzed reduced 99mTc levels for all IDA radiopharmaceuticals. The miniaturized chromatography procedure, as outlined, is rapid, taking less than 4 min, and can easily be incorporated into the daily quality control program in any nuclear medicine facility.

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Year:  1982        PMID： 6282594     DOI： 10.1007/bf00251651

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  13 in total

1.  Rapid determination of oxidation state of unbound 99mTc and labeling yield in 99mTc-labeled radiopharmaceuticals.

Authors:  L G Colombetti; S Moerlien; G C Patel; S M Pinsky
Journal:  J Nucl Med       Date:  1976-09       Impact factor: 10.057

2.  Gel chromatography column scanning for the analysis of 99mTc-labelled compounds.

Authors:  B R Persson; L Darte
Journal:  J Chromatogr       Date:  1974-12-18

3.  Chromatographic quality control of 99mTc-labeled compounds.

Authors:  M W Billinghurst
Journal:  J Nucl Med       Date:  1973-11       Impact factor: 10.057

4.  A simplified radiochromatographic purity check.

Authors:  R F Gutkowski; H J Dworkin
Journal:  J Nucl Med       Date:  1971-07       Impact factor: 10.057

5.  Chemical state of 99mTc in biomedical products.

Authors:  W Eckelman; G Meinken; P Richards
Journal:  J Nucl Med       Date:  1971-09       Impact factor: 10.057

6.  Quality control of 99mTc-radiopharmaceuticals. Evaluation of GCS minicolumns in routine clinical work with scintillation cameras.

Authors:  L Darte; B R Persson
Journal:  Eur J Nucl Med       Date:  1980-12

7.  Rapid miniaturized chromatographic quality control procedures for iodinated radiopharmaceuticals.

Authors:  A M Zimmer; D G Pavel
Journal:  Am J Hosp Pharm       Date:  1978-04

8.  99MTc-HIDA, a gallbladder imaging agent: experimental aspects.

Authors:  E Chiotellis; C Sawas-Dimopoulou; C Koutoulidis; M Constantinides
Journal:  Eur J Nucl Med       Date:  1978

9.  Development of new radiopharmaceuticals based on N-substitution of iminodiacetic acid.

Authors:  M D Loberg; M Cooper; E Harvey; P Callery; W Faith
Journal:  J Nucl Med       Date:  1976-07       Impact factor: 10.057

10.  The chemical state of 99m Tc in biomedical products. II. The chelation of reduced technetium with DTPA.

Authors:  W C Eckelman; G Meinken; P Richards
Journal:  J Nucl Med       Date:  1972-08       Impact factor: 10.057
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  4 in total

1.  A single-strip mini-paper chromatographic method for rapid purity-control of 99mTc-labeled radiopharmaceuticals.

Authors:  S Sanada; A Ando; I Ando; T Hiraki; K Hisada
Journal:  Eur J Nucl Med       Date:  1986

2.  Pharmacokinetic studies of DISIDA disposition. I. Animal studies.

Authors:  I A Fraser; P Shaffer; J Love; A E Staubus; G Hinkle; J Olsen; L C Carey; P J Fabri; E C Ellison
Journal:  Eur J Nucl Med       Date:  1988

3.  Pharmacokinetic studies of DISIDA disposition. II. Clinical studies.

Authors:  J E Love; P Shaffer; I A Fraser; A E Staubus; J A Lott; G Hinkle; L C Carey; E C Ellison; P J Fabri
Journal:  Eur J Nucl Med       Date:  1988

4.  The stability of 99mTc-DTPA and 99mTc-HIDA following ultrasonic nebulisation.

Authors:  N Durovic; M Pillay; P H Cox
Journal:  Eur J Nucl Med       Date:  1988
  4 in total

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