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Literature DB >> 6282206

In vitro activity of moxalactam and mecillinam, singly and in combination, against multi-drug-resistant Enterobacteriaceae and Pseudomonas species.

Abstract

The in vitro interaction of moxalactam and mecillinam against multi-drug-resistant gram-negative enteric bacilli was studied by checkerboard microdilution susceptibility tests and by killing curve kinetics. Against Enterobacteriaceae, the combination was unpredictable; the frequencies of synergy, indifference, and antagonism were 11, 76, and 13%, respectively. Against Pseudomonas sp., the two drugs were consistently indifferent. Overall, the combination of moxalactam and mecillinam was no more active than moxalactam alone.

Entities: Chemical Species

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Year: 1982 PMID： 6282206 PMCID： PMC181852 DOI： 10.1128/AAC.21.1.188

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

12 in total

7. Moxalactam (6059-S), a new 1-oxa-beta-lactam: binding affinity for penicillin-binding proteins of Escherichia coli K-12.

Authors: Y Komatsu; T Nishikawa
Journal: Antimicrob Agents Chemother Date: 1980-03 Impact factor: 5.191

Review 8. In vitro susceptibilities of nonfermentative gram-negative bacilli other than Pseudomonas aeruginosa to 32 antimicrobial agents.

Authors: R J Fass; J Barnishan
Journal: Rev Infect Dis Date: 1980 Nov-Dec

9. In vitro activities of beta-lactam and aminoglycoside antibiotics. A comparative study of 20 parenterally administered drugs.

Authors: R J Fass
Journal: Arch Intern Med Date: 1980-06

10. In vitro activity of LY127935.

Authors: R J Fass
Journal: Antimicrob Agents Chemother Date: 1979-10 Impact factor: 5.191

1 in total

1. Comparative in vitro activities of azlocillin-cefotaxime and azlocillin-tobramycin combinations against blood and multi-drug resistant bacterial isolates.

Authors: R J Fass
Journal: Antimicrob Agents Chemother Date: 1982-07 Impact factor: 5.191

1 in total

In vitro activity of moxalactam and mecillinam, singly and in combination, against multi-drug-resistant Enterobacteriaceae and Pseudomonas species.

1. Antagonism of the antibacterial action of some penicillins by other penicillins and cephalosporins.

2. Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12.

3. Mecillinam (FL 1060), a 6beta-amidinopenicillanic acid derivative: bactericidal action and synergy in vitro.

4. Emergence of resistance to cefamandole: possible role of cefoxitin-inducible beta-lactamases.

5. Effect of clindamycin on the in vitro activity of amikacin and gentamicin against gram-negative bacilli.

6. Synergy of mecillinam, a beta-amidinopenicillanic acid derivative, combined with beta-lactam antibiotics.

7. Moxalactam (6059-S), a new 1-oxa-beta-lactam: binding affinity for penicillin-binding proteins of Escherichia coli K-12.

Review 8. In vitro susceptibilities of nonfermentative gram-negative bacilli other than Pseudomonas aeruginosa to 32 antimicrobial agents.

9. In vitro activities of beta-lactam and aminoglycoside antibiotics. A comparative study of 20 parenterally administered drugs.

10. In vitro activity of LY127935.

1. Comparative in vitro activities of azlocillin-cefotaxime and azlocillin-tobramycin combinations against blood and multi-drug resistant bacterial isolates.