Literature DB >> 6281377

Properties of monoclonal antibodies directed against the glycoproteins of Sindbis virus.

J T Roehrig, D Gorski, M J Schlesinger.   

Abstract

Four monoclonal antibodies that react with Sindbis virus glycoproteins have been examined for (i) their effects on virus infectivity, (ii) their ability to recognize conformational changes in glycoprotein structure, and (iii) their cross-reaction with several different alphaviruses. Two of the monoclonal antibodies reacted with the native forms of the E1 glycoprotein but did not neutralize virus infectivity. One of the anti-E1 antibodies formed an infectious virus-antibody complex. The other two monoclonal antibodies reacted with the E2 glycoprotein in both an unfolded as well as a native structure. One of these antibodies reacted with Semliki Forest virus. The anti-E1, but not the anti-E2, antibodies cross-reacted with three serologically related equine encephalomyelitis viruses.

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Year:  1982        PMID： 6281377     DOI： 10.1099/0022-1317-59-2-421

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  14 in total

1.  Use of a lambda gt11 expression library to localize a neutralizing antibody-binding site in glycoprotein E2 of Sindbis virus.

Authors:  K S Wang; J H Strauss
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

2.  Identification of antigenically important domains in the glycoproteins of Sindbis virus by analysis of antibody escape variants.

Authors:  E G Strauss; D S Stec; A L Schmaljohn; J H Strauss
Journal:  J Virol       Date:  1991-09       Impact factor: 5.103

3.  Detection of alphaviruses in a genus-specific antigen capture enzyme immunoassay using monoclonal antibodies.

Authors:  I M Greiser-Wilke; V Moennig; O R Kaaden; R E Shope
Journal:  J Clin Microbiol       Date:  1991-01       Impact factor: 5.948

4.  Localization of four antigenic sites involved in Venezuelan equine encephalomyelitis virus protection.

Authors:  E V Agapov; I A Razumov; I V Frolov; A A Kolykhalov; S V Netesov; V B Loktev
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574

5.  Immunological characterisation of the rubella E 1 glycoprotein. Brief report.

Authors:  L Ho-Terry; G M Terry; A Cohen; P Londesborough
Journal:  Arch Virol       Date:  1986       Impact factor: 2.574

6.  Sindbis virus mutations which coordinately affect glycoprotein processing, penetration, and virulence in mice.

Authors:  D L Russell; J M Dalrymple; R E Johnston
Journal:  J Virol       Date:  1989-04       Impact factor: 5.103

Review 7.  The alphaviruses: gene expression, replication, and evolution.

Authors:  J H Strauss; E G Strauss
Journal:  Microbiol Rev       Date:  1994-09

8.  Sindbis virus attachment: isolation and characterization of mutants with impaired binding to vertebrate cells.

Authors:  J Dubuisson; C M Rice
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

9.  Identification of immunologically cross-reactive proteins of Sindbis virus: evidence for unique conformation of E1 glycoprotein from infected cells.

Authors:  J A Wolcott; C J Wust; A Brown
Journal:  J Virol       Date:  1984-02       Impact factor: 5.103

10.  Conformational alteration of Sindbis virion glycoproteins induced by heat, reducing agents, or low pH.

Authors:  W J Meyer; S Gidwitz; V K Ayers; R J Schoepp; R E Johnston
Journal:  J Virol       Date:  1992-06       Impact factor: 5.103
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