Literature DB >> 6280685

Adenosine production inside rat polymorphonuclear leucocytes.

A C Newby, C A Holmquist.   

Abstract

Adenosine synthesis was studied during 2-deoxyglucose-induced ATP catabolism in intact rat polymorphonuclear leucocytes. When both adenosine kinase (EC 2.7.1.20) and adenosine deaminase (EC 3.5.4.4) were selectively inhibited, adenosine accumulated. Adenosine formation took place inside the intact cells by a metabolic pathway independent of the ecto-5'-nucleotidase (EC 3.1.3.5). Distinct metabolic pathways are proposed for adenosine production from intracellular or extracellular nucleotides.

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Year:  1981        PMID： 6280685      PMCID： PMC1163548          DOI： 10.1042/bj2000399

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

Review 1.  REGULATION OF CORONARY BLOOD FLOW.

Authors:  R M BERNE
Journal:  Physiol Rev       Date:  1964-01       Impact factor: 37.312

2.  Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex.

Authors:  J W Phillis; J P Edstrom; G K Kostopoulos; J R Kirkpatrick
Journal:  Can J Physiol Pharmacol       Date:  1979-11       Impact factor: 2.273

3.  Adenine nucleotides in cholinergic transmission: presynaptic aspects.

Authors:  M J Dowdall
Journal:  J Physiol (Paris)       Date:  1978

Review 4.  The role of adenosine in the regulation of coronary blood flow.

Authors:  R M Berne
Journal:  Circ Res       Date:  1980-12       Impact factor: 17.367

5.  Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture.

Authors:  J D Pearson; J S Carleton; J L Gordon
Journal:  Biochem J       Date:  1980-08-15       Impact factor: 3.857

6.  Subcellular distribution and movement of 5'-nucleotidase in rat cells.

Authors:  K K Stanley; M R Edwards; J P Luzio
Journal:  Biochem J       Date:  1980-01-15       Impact factor: 3.857

7.  The interaction of inhibitors with adenosine metabolising enzymes in intact isolated cells.

Authors:  A C Newby
Journal:  Biochem Pharmacol       Date:  1981-09-15       Impact factor: 5.858

8.  Role of adenosine deaminase, ecto-(5'-nucleotidase) and ecto-(non-specific phosphatase) in cyanide-induced adenosine monophosphate catabolism in rat polymorphonuclear leucocytes.

Authors:  A C Newby
Journal:  Biochem J       Date:  1980-03-15       Impact factor: 3.857

9.  Study of the cytotoxicity and metabolism of 4-amino-3-carboxamido-1-(beta-D-ribofuranosyl)pyrazolo[3,4-d]pyrimidine using inhibitors of adenosine kinase and adenosine deaminase.

Authors:  L L Wotring; L B Townsend
Journal:  Cancer Res       Date:  1979-08       Impact factor: 12.701

10.  Role of S-adenosylhomocysteine hydrolase in adenosine metabolism in mammalian heart.

Authors:  J Schrader; W Schütz; H Bardenheuer
Journal:  Biochem J       Date:  1981-04-15       Impact factor: 3.857
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  22 in total

1.  Inhibition of IMP-specific cytosolic 5'-nucleotidase and adenosine formation in rat polymorphonuclear leucocytes by 5'-deoxy-5'-isobutylthio derivatives of adenosine and inosine.

Authors:  A C Skladanowski; G B Sala; A C Newby
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

2.  Cultured lymphocytes from alcoholic subjects have altered cAMP signal transduction.

Authors:  L E Nagy; I Diamond; A Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

Review 3.  Regulation of neutrophil function by adenosine.

Authors:  Kathryn E Barletta; Klaus Ley; Borna Mehrad
Journal:  Arterioscler Thromb Vasc Biol       Date:  2012-04       Impact factor: 8.311

4.  The soluble 'low-Km' 5'-nucleotidase of rat kidney represents solubilized ecto-5'-nucleotidase.

Authors:  G Piec; M Le Hir
Journal:  Biochem J       Date:  1991-01-15       Impact factor: 3.857

5.  Intracellular adenosine in isolated rat liver cells.

Authors:  F L Belloni; R Rubio; R M Berne
Journal:  Pflugers Arch       Date:  1984-01       Impact factor: 3.657

6.  Nucleoside exchange catalysed by the cytoplasmic 5'-nucleotidase.

Authors:  Y Worku; A C Newby
Journal:  Biochem J       Date:  1982-09-01       Impact factor: 3.857

7.  A new procedure for haptenizing adenosine leading to a more specific radioimmunoassay method.

Authors:  A C Newby; G B Sala
Journal:  Biochem J       Date:  1982-12-15       Impact factor: 3.857

8.  Solubilization and purification of rat liver 5'-nucleotidase by use of a zwitterionic detergent and a monoclonal-antibody immunoadsorbent.

Authors:  E M Bailyes; A C Newby; K Siddle; J P Luzio
Journal:  Biochem J       Date:  1982-04-01       Impact factor: 3.857

9.  The control of adenosine concentration in polymorphonuclear leucocytes, cultured heart cells and isolated perfused heart from the rat.

Authors:  A C Newby; C A Holmquist; J Illingworth; J D Pearson
Journal:  Biochem J       Date:  1983-08-15       Impact factor: 3.857

10.  Purine catabolism in polymorphonuclear neutrophils. Phorbol myristate acetate-induced accumulation of adenosine owing to inactivation of extracellularly released adenosine deaminase.

Authors:  G van Waeg; G Van den Berghe
Journal:  J Clin Invest       Date:  1991-01       Impact factor: 14.808
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