Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Spinal sympathetic neurons: possible sites of opiate-withdrawal suppression by clonidine.

Literature DB >> 6280276

Spinal sympathetic neurons: possible sites of opiate-withdrawal suppression by clonidine.

Abstract

Morphine, methadone, meperidine, fentanyl, and clonidine rapidly depressed transmission through sympathetic preganglionic neurons in cats with the spinal cord transected. Naloxone promptly antagonized this effect of the opiates but not that of clonidine which was reversed by alpha 2-adrenergic receptor antagonists. The independent depression of preganglionic neurons by clonidine may contribute to the ability of this drug to depress the symptoms of opiate withdrawal that are characterized by sympathetic hyperactivity.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1982 PMID： 6280276 DOI： 10.1126/science.6280276

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

Keyword Cloud
Cited

12 in total

1. Activation of coeruleospinal noradrenergic inhibitory controls during withdrawal from morphine in the rat.

Authors: D S Rohde; A I Basbaum
Journal: J Neurosci Date: 1998-06-01 Impact factor: 6.167

2. Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats.

Authors: J R Taylor; V O Lewis; J D Elsworth; P Pivirotto; R H Roth; D E Redmond
Journal: Psychopharmacology (Berl) Date: 1991 Impact factor: 4.530

3. Social, motor, and autonomic signs of morphine withdrawal: differential sensitivities to catecholaminergic drugs in mice.

Authors: K M Kantak; K A Miczek
Journal: Psychopharmacology (Berl) Date: 1988 Impact factor: 4.530

10. Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal.

Authors: J R Taylor; J D Elsworth; E J Garcia; S J Grant; R H Roth; D E Redmond
Journal: Psychopharmacology (Berl) Date: 1988 Impact factor: 4.530

Spinal sympathetic neurons: possible sites of opiate-withdrawal suppression by clonidine.

1. Activation of coeruleospinal noradrenergic inhibitory controls during withdrawal from morphine in the rat.

2. Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats.

3. Social, motor, and autonomic signs of morphine withdrawal: differential sensitivities to catecholaminergic drugs in mice.

Review 4. Neurochemistry of bulbospinal presympathetic neurons of the medulla oblongata.

5. Effect of clonidine, nimodipine and diltiazem on the in vitro opioid withdrawal response in the guinea-pig ileum.

6. Effects of alpha 2-agonists on morphine withdrawal behaviour: potentiation of jumping mediated by alpha 2-receptors.

7. Studies with alpha 2-adrenoceptor agonists and alcohol abstinence syndrome in rats.

8. Fentanyl antagonizes diazepam on carotid sinus baroreflex control of circulation in rabbits.

9. Efficacy of clonidine in treatment of alcohol withdrawal state.

10. Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal.