Literature DB >> 6279623

Insulin acutely increases phospholipids in the phosphatidate-inositide cycle in rat adipose tissue.

R V Farese, R E Larson, M A Sabir.   

Abstract

Administration of insulin in vivo provoked rapid (near maximal in 30 min) increases (65-90%) in the concentrations of phosphatidic acid, phosphatidylinositol, and polyphosphoinositides in rat adipose tissue. Insulin also increased phosphatidylinositol levels in adipocytes incubated in vitro. Dose-response relationships suggested that these effects of insulin were physiologically relevant. The enrichment of membranes with acidic phospholipids in the phosphatidate-inositide cycle may play a role in the action of insulin in adipocytes.

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Year:  1982        PMID： 6279623

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  13 in total

1.  Phosphatidylinositol kinase activity in virus-transformed and nontransformed cells.

Authors:  S Sugano; H Hanafusa
Journal:  Mol Cell Biol       Date:  1985-09       Impact factor: 4.272

2.  Purification of a phosphatidylinositol-glycan-specific phospholipase C from liver plasma membranes: a possible target of insulin action.

Authors:  J A Fox; N M Soliz; A R Saltiel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

3.  Plasma membrane phospholipid content in non-insulin-dependent streptozotocin-diabetic rats--effect of insulin.

Authors:  J Levy; Y Suzuki; L V Avioli; G Grunberger; J R Gavin
Journal:  Diabetologia       Date:  1988-05       Impact factor: 10.122

4.  Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding.

Authors:  G van de Werve; J Proietto; B Jeanrenaud
Journal:  Biochem J       Date:  1985-01-15       Impact factor: 3.857

5.  Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. Relationship to the metabolic effects of insulin and insulin-like agents.

Authors:  T W Honeyman; W Strohsnitter; C R Scheid; R J Schimmel
Journal:  Biochem J       Date:  1983-05-15       Impact factor: 3.857

6.  Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes.

Authors:  J Smal; P De Meyts
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

7.  Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis.

Authors:  I G Macara; G V Marinetti; P C Balduzzi
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

8.  Phospholipids and the regulation of pyruvate dehydrogenase from rat adipocyte mitochondria.

Authors:  F L Kiechle; L Jarett
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

9.  The de novo phospholipid effect of insulin is associated with increases in diacylglycerol, but not inositol phosphates or cytosolic Ca2+.

Authors:  R V Farese; J S Davis; D E Barnes; M L Standaert; J S Babischkin; R Hock; N K Rosic; R J Pollet
Journal:  Biochem J       Date:  1985-10-15       Impact factor: 3.857

10.  Effects of insulin and prior exercise on prostaglandin release from perfused rat muscle. Evidence that prostaglandins do not mediate changes in glucose uptake.

Authors:  A Zorzano; T W Balon; J A Jakubowski; M N Goodman; D Deykin; N B Ruderman
Journal:  Biochem J       Date:  1986-12-01       Impact factor: 3.857
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