Literature DB >> 3883992

Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding.

G van de Werve, J Proietto, B Jeanrenaud.   

Abstract

In isolated rat adipocytes, tumour-promoting phorbol esters caused (1) dose-dependent stimulation of lipogenesis in the absence of insulin and (2) inhibition of the lipogenic effect of submaximal concentrations of insulin, but without affecting insulin binding. The possible involvement of protein kinase C in insulin action is discussed.

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Year:  1985        PMID： 3883992      PMCID： PMC1144619          DOI： 10.1042/bj2250523

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  22 in total

1.  The effect of insulin on 32Pi incorporation into rat fat cell phospholipids.

Authors:  J M Stein; C N Hales
Journal:  Biochim Biophys Acta       Date:  1974-01-23

2.  The action of insulin on the incorporation of [32P]phosphate in the phospholipids of rat adipose tissue.

Authors:  G De Torrontegui; J Berthet
Journal:  Biochim Biophys Acta       Date:  1966-06-01

3.  A simple free fat cell bioassay for insulin.

Authors:  A J Moody; M A Stan; M Stan; J Gliemann
Journal:  Horm Metab Res       Date:  1974-01       Impact factor: 2.936

4.  Inhibition of epidermal growth factor binding to surface receptors by tumor promotors.

Authors:  K D Brown; P Dicker; E Rozengurt
Journal:  Biochem Biophys Res Commun       Date:  1979-02-28       Impact factor: 3.575

5.  Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. Relationship to the metabolic effects of insulin and insulin-like agents.

Authors:  T W Honeyman; W Strohsnitter; C R Scheid; R J Schimmel
Journal:  Biochem J       Date:  1983-05-15       Impact factor: 3.857

6.  Insulin activates phospholipase C in fat cells: similarity with the activation of pyruvate dehydrogenase.

Authors:  B Koepfer-Hobelsberger; O H Wieland
Journal:  Mol Cell Endocrinol       Date:  1984-06       Impact factor: 4.102

7.  The mechanism of action of insulin on phospholipid metabolism in rat adipose tissue. Requirement for protein synthesis and a carbohydrate source, and relationship to activation of pyruvate dehydrogenase.

Authors:  R V Farese; R V Farese; M A Sabir; R E Larson; W L Trudeau; D Barnes
Journal:  Diabetes       Date:  1984-07       Impact factor: 9.461

8.  Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Authors:  M Castagna; Y Takai; K Kaibuchi; K Sano; U Kikkawa; Y Nishizuka
Journal:  J Biol Chem       Date:  1982-07-10       Impact factor: 5.157

9.  Effect of insulin, catecholamines and calcium ions on phospholipid metabolism in isolated white fat-cells.

Authors:  J A García-Sáinz; J N Fain
Journal:  Biochem J       Date:  1980-03-15       Impact factor: 3.857

10.  Inhibition of insulin receptor binding by phorbol esters.

Authors:  P Thomopoulos; U Testa; M F Gourdin; C Hervy; M Titeux; W Vainchenker
Journal:  Eur J Biochem       Date:  1982-12-15
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  18 in total

1.  Epidermal growth factor counteracts the glycogenic effect of insulin in parenchymal hepatocyte cultures.

Authors:  M H Chowdhury; L Agius
Journal:  Biochem J       Date:  1987-10-15       Impact factor: 3.857

2.  Insulin, oxytocin, and vasopressin stimulate protein kinase C activity in adipocyte plasma membranes.

Authors:  J J Egan; J Saltis; S A Wek; I A Simpson; C Londos
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

3.  Protein kinase C activators selectively inhibit insulin-stimulated system A transport activity in skeletal muscle at a post-receptor level.

Authors:  A Gumà; M Camps; M Palacín; X Testar; A Zorzano
Journal:  Biochem J       Date:  1990-06-15       Impact factor: 3.857

4.  Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

Authors:  G E Bollag; R A Roth; J Beaudoin; D Mochly-Rosen; D E Koshland
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

5.  Control of glycogen phosphorylase interconversion by phorbol esters, diacylglycerols, Ca2+ and hormones in isolated rat hepatocytes.

Authors:  G van de Werve; J Proietto; B Jeanrenaud
Journal:  Biochem J       Date:  1985-11-01       Impact factor: 3.857

6.  Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes.

Authors:  C M Heyworth; A D Whetton; S Wong; B R Martin; M D Houslay
Journal:  Biochem J       Date:  1985-06-15       Impact factor: 3.857

7.  Human islet amyloid polypeptide at pharmacological levels inhibits insulin and phorbol ester-stimulated glucose transport in in vitro incubated human muscle strips.

Authors:  J R Zierath; D Galuska; A Engström; K H Johnson; C Betsholtz; P Westermark; H Wallberg-Henriksson
Journal:  Diabetologia       Date:  1992-01       Impact factor: 10.122

8.  Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes.

Authors:  J Smal; P De Meyts
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

9.  Signal transduction convergence: phorbol esters and insulin inhibit phosphoenolpyruvate carboxykinase gene transcription through the same 10-base-pair sequence.

Authors:  R M O'Brien; M T Bonovich; C D Forest; D K Granner
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

10.  Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes.

Authors:  D J Stumpo; P J Blackshear
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205
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