| Literature DB >> 6279242 |
A Trevisani, C Biondi, O Belluzzi, P G Borasio, A Capuzzo, M E Ferretti, V Perri.
Abstract
Prostaglandins of the E type (PGEs) stimulate cyclic adenosine 3',5'-monophosphate (cAMP) biosynthesis both in isolated preparations of rat, guinea-pig and rabbit superior cervical ganglia (SCG) and in calf SCG slices. Electrical stimulation of preganglionic nerve fibers of the guinea-pig SCG remarkably increased PGE release and cAMP biosynthesis. These effects were blocked by reducing the Ca2+ to Mg2+ ratio in the incubation medium. Atropine (1 microM) and phentolamine (10 microM) inhibited PGE biosynthesis and significantly reduced cAMP levels.Entities:
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Year: 1982 PMID: 6279242 DOI: 10.1016/0006-8993(82)90722-3
Source DB: PubMed Journal: Brain Res ISSN: 0006-8993 Impact factor: 3.252