Literature DB >> 6278422

Moloney murine leukemia virus-induced tumors: recombinant proviruses in active chromatin regions.

H van der Putten, W Quint, I M Verma, A Berns.   

Abstract

The DNase I sensitivity of chromosomal DNA regions carrying integrated proviral genomes of Moloney (M-MuLV) and AKR Murine Leukemia Virus (AKR-MuLV), and the cellular homologue of the mos-gene (c-mos) of Moloney Sarcoma Virus (MSV) were studied in tumor tissues of leukemic mice. The genetically transmitted sequences of M-MuLV, AKR-MuLV, and the c-mos gene are all in DNase I resistant chromatin conformations in M-MuLV-induced tumors. Each M-MuLV-induced tumor contained at least one somatically acquired integrated recombinant MuLV genome that displayed two main characteristic features of active chromatin: a) a configuration hypersensitive to DNase I, and b) extensive hypomethylation. DNase I hypersensitive sites were mapped at the junction of cellular sequences and the 5'-viral large terminal repeat (LTR). Expression of a recombinant MuLV seems therefore to be a necessary feature to maintain the transformed state.

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Year:  1982        PMID： 6278422      PMCID： PMC326159          DOI： 10.1093/nar/10.2.577

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  27 in total

Review 1.  The Fv-1 gene of the mouse and its control of murine leukemia virus replication.

Authors:  P Jolicoeur
Journal:  Curr Top Microbiol Immunol       Date:  1979       Impact factor: 4.291

2.  Leukemogenicity of clonal isolates of murine leukemia viruses.

Authors:  P Jolicoeur; N Rosenberg; A Cotellessa; D Baltimore
Journal:  J Natl Cancer Inst       Date:  1978-06       Impact factor: 13.506

3.  Moloney leukemia virus gene expression and gene amplification in preleukemic and leukemic BALB/Mo mice.

Authors:  R Jaenisch
Journal:  Virology       Date:  1979-02       Impact factor: 3.616

4.  The integrated genome of murine leukemia virus.

Authors:  D Steffen; R A Weinberg
Journal:  Cell       Date:  1978-11       Impact factor: 41.582

5.  Germ line integration of Moloney leukemia virus: identification of the chromosomal integration site.

Authors:  M Breindl; J Doehmer; K Willecke; J Dausman; R Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

6.  Identification of DNA fragments carrying ecotropic proviruses of AKR mice.

Authors:  D Steffen; S Bird; W P Rowe; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

7.  Restriction enzyme analysis of mouse cellular type C viral DNA: emergence of new viral sequences in spontaneous AKR/J lymphomas.

Authors:  E Canaani; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

8.  Increase of AKR-specific sequences in tumor tissues of leukemic AKR mice.

Authors:  A Berns; R Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

9.  Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal.

Authors:  R Jaenisch; H Fan; B Croker
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

10.  The integration sites of endogenous and exogenous Moloney murine leukemia virus.

Authors:  H van der Putten; E Terwindt; A Berns; R Jaenisch
Journal:  Cell       Date:  1979-09       Impact factor: 41.582
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  10 in total

1.  Viral sequences are associated with many histocompatibility genes.

Authors:  A Rossomando; D Meruelo
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

2.  Evolution of the single copy alpha A-crystallin gene: differently sized mRNAs of mammals and birds show homology in their 3' non-coding regions.

Authors:  H J Dodemont; W J Quax; J G Schoenmakers; H Bloemendal
Journal:  Mol Biol Rep       Date:  1985-10       Impact factor: 2.316

3.  Significance of DNase I-hypersensitive sites in the long terminal repeats of a Moloney murine leukemia virus vector.

Authors:  J A Rasmussen; E Gilboa
Journal:  J Virol       Date:  1987-05       Impact factor: 5.103

Review 4.  Retroviral-mediated gene transfer. Applications in neurobiology.

Authors:  M M Lo; M K Conrad; C Mamalaki; M J Kadan
Journal:  Mol Neurobiol       Date:  1988       Impact factor: 5.590

5.  Developmental fate of a human insulin gene in a transgenic mouse.

Authors:  H van der Putten; F Botteri; K Illmensee
Journal:  Mol Gen Genet       Date:  1984

6.  Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites.

Authors:  H Rohdewohld; H Weiher; W Reik; R Jaenisch; M Breindl
Journal:  J Virol       Date:  1987-02       Impact factor: 5.103

7.  Retrovirus-induced interference with collagen I gene expression in Mov13 fibroblasts is maintained in the absence of DNA methylation.

Authors:  H Chan; S Hartung; M Breindl
Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

8.  The changes in proviral chromatin that accompany morphological variation in avian sarcoma virus-infected rat cells.

Authors:  D J Chiswell; D A Gillespie; J A Wyke
Journal:  Nucleic Acids Res       Date:  1982-07-10       Impact factor: 16.971

9.  Spontaneous germ line virus infection and retroviral insertional mutagenesis in eighteen transgenic Srev lines of mice.

Authors:  S E Spence; D J Gilbert; D A Swing; N G Copeland; N A Jenkins
Journal:  Mol Cell Biol       Date:  1989-01       Impact factor: 4.272

10.  In vitro methylation of specific regions of the cloned Moloney sarcoma virus genome inhibits its transforming activity.

Authors:  M L McGeady; C Jhappan; R Ascione; G F Vande Woude
Journal:  Mol Cell Biol       Date:  1983-03       Impact factor: 4.272
  10 in total

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