| Literature DB >> 6278093 |
A Arregui, E K Perry, M Rossor, B E Tomlinson.
Abstract
The activity of the dipeptidyl carboxypeptidase, angiotensin converting enzyme, was assayed in several brain regions of patients dying with Alzheimer's disease and compared to that of appropriately age-matched controls. Enzyme activity was found to be elevated by 44% and 41% in the medial hippocampus and parahippocampal gyrus, respectively, and by 27% and 29% in the frontal cortex (area 10 of Brodman) and caudate nucleus, respectively, in Alzheimer's disease patients. Converting enzyme activity did not differ from controls in the nucleus accumbens, substantia nigra, temporal cortex, anterior or posterior hippocampus, amydgala, and septal nuclei.Entities:
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Year: 1982 PMID： 6278093 DOI： 10.1111/j.1471-4159.1982.tb07930.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372