| Literature DB >> 6277739 |
K J Denniston, M J Madden, L W Enquist, G Vande Woude.
Abstract
We describe the characterization of 34 hybrid lambda bacteriophages carrying EcoRI fragments obtained from DNA of defective interfering particles of the Patton strain of Herpes simplex virus type 1 (HSV-1). All cloned fragments contained S region terminal repeat sequences (TRs) fused to unique HSV-1 DNA. Several fragments contained deletions and rearrangements not described previously for DNA of HSV-1 defective interfering particles. A model describing the generation of defective interfering DNA based on recombination events involving the terminal "a" sequence as presented.Entities:
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Year: 1981 PMID: 6277739 DOI: 10.1016/0378-1119(81)90180-3
Source DB: PubMed Journal: Gene ISSN: 0378-1119 Impact factor: 3.688