Literature DB >> 6276719

Involvement of histone H1 in the structure of the linker DNA in nucleosomes as revealed by nucleases.

J J Lawrence, P Goeltz.   

Abstract

This report describes experiments designed to study the organization of the linker DNA in nucleosomes. When rat liver nucleosomes (145 to 188 base pairs in length) were digested by Exonuclease III and then by nuclease S1 a series of bands on sizes 90 - 102 - 112 - 125 - 135 - 142 - 154 - 166 - 172 - 181 - bases was observed in denaturing electrophoretic gels. Digestion of H1-depleted nucleosomes under the same conditions results in a series of products of sizes (10.4) xn in base (n less than or equal to 14) only. This result is interpreted as reflecting a particular arrangement of linker DNA under the influence of histone H1.

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Year:  1981        PMID： 6276719     DOI： 10.1007/bf00798384

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  31 in total

1.  Internal structure of the chromatin subunit.

Authors:  M Noll
Journal:  Nucleic Acids Res       Date:  1974-11       Impact factor: 16.971

2.  Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis.

Authors:  T Maniatis; A Jeffrey; H van deSande
Journal:  Biochemistry       Date:  1975-08-26       Impact factor: 3.162

3.  Removal of histone H1 exposes a fifty base pair DNA segment between nucleosomes.

Authors:  J P Whitlock; R T Simpson
Journal:  Biochemistry       Date:  1976-07-27       Impact factor: 3.162

Review 4.  Structure of chromatin.

Authors:  R D Kornberg
Journal:  Annu Rev Biochem       Date:  1977       Impact factor: 23.643

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Action of micrococcal nuclease on chromatin and the location of histone H1.

Authors:  M Noll; R D Kornberg
Journal:  J Mol Biol       Date:  1977-01-25       Impact factor: 5.469

7.  Distribution of linker DNA in relation to core DNA in H1 depleted nucleosomes.

Authors:  J J Lawrence; P Goeltz
Journal:  Nucleic Acids Res       Date:  1981-02-25       Impact factor: 16.971

8.  Nucleosomal DNA is digested to repeats of 10 bases by exonuclease III.

Authors:  D Riley; H Weintraub
Journal:  Cell       Date:  1978-02       Impact factor: 41.582

9.  Selective removal of histone H1 from nucleosomes at low ionic strength.

Authors:  S P Modak; J J Lawrence; C Gorka
Journal:  Mol Biol Rep       Date:  1980-12-31       Impact factor: 2.316

10.  DNA folding in the nucleosome.

Authors:  M Noll
Journal:  J Mol Biol       Date:  1977-10-15       Impact factor: 5.469
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