Literature DB >> 6273956

Pharmacological activity of leukotrienes A4, B4, C4 and D4 on selected guinea-pig, rat, rabbit and human smooth muscles.

P Sirois, S Roy, J P Tétrault, P Borgeat, S Picard, E J Corey.   

Abstract

The myotropic activity of leukotrienes A4, B4, C4, D4 and histamine has been evaluated on selected smooth muscle preparations. LTA4, B4, C4 and D4 were several times more potent than histamine on the guinea-pig lung parenchymal strip, while on the guinea-pig trachea, LTB4 was less active. The guinea-pig ileum either in segments or in strips of longitudinal muscles responses well to LTC4, LTD4 and histamine but not to LTA4 and LTB4. Rat and rabbit lung parenchymal strip showed very little sensitivity for leukotrienes whereas human parenchymal strips and bronchi were nearly as sensitive as the guinea-pig lung.

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Year:  1981        PMID： 6273956     DOI： 10.1016/0161-4630(81)90137-3

Source DB:  PubMed          Journal:  Prostaglandins Med        ISSN： 0161-4630


  12 in total

1.  The mechanism of action of leukotrienes A4, C4 and D4 on human lung parenchyma in vitro.

Authors:  M Chagnon; J Gentile; M Gladu; P Sirois
Journal:  Lung       Date:  1985       Impact factor: 2.584

2.  Immunological and non-immunological release of leukotrienes and histamine from human nasal polyps.

Authors:  H Salari; P Borgeat; S Steffenrud; J Richard; P M Bédard; J Hébert; G Pelletier
Journal:  Clin Exp Immunol       Date:  1986-03       Impact factor: 4.330

3.  Immunological and non-immunological release of leukotrienes and histamine by guinea-pig heart.

Authors:  H Salari
Journal:  Immunology       Date:  1986-07       Impact factor: 7.397

4.  The effects of leukotrienes, thromboxane A2 and phospholipase A2 on human, porcine and guinea pig lung parenchyma.

Authors:  F J Zijlstra; J E Vincent; I L Bonta
Journal:  Agents Actions       Date:  1984-01

Review 5.  Leukotrienes: a new approach to the biochemistry of hypersensitivity.

Authors:  P Sirois; P Borgeat
Journal:  Surv Immunol Res       Date:  1982

6.  Pre- and post-junctional actions of prostaglandin I2, carbocyclic thromboxane A2 and leukotriene C4 in dog tracheal tissue.

Authors:  T Inoue; Y Ito
Journal:  Br J Pharmacol       Date:  1985-02       Impact factor: 8.739

7.  Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects.

Authors:  N C Barnes; P J Piper; J F Costello
Journal:  Thorax       Date:  1984-07       Impact factor: 9.139

8.  Platelet-activating factor stimulates eicosanoid production in cultured feline tracheal epithelial cells.

Authors:  T Wu; R D Rieves; C Logun; J H Shelhamer
Journal:  Lung       Date:  1995       Impact factor: 2.584

9.  The contractile action of leukotriene B4 in the guinea-pig lung involves a vascular component.

Authors:  Kiyoto Sakata; Sven-Erik Dahlén; Magnus Bäck
Journal:  Br J Pharmacol       Date:  2004-01-12       Impact factor: 8.739

10.  Guinea pig bronchus as a model for icosanoid studies.

Authors:  P Sirois; S Prié; P Thériault; G Rouleau; M Lauzière
Journal:  Inflammation       Date:  1987-12       Impact factor: 4.092
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