Literature DB >> 6273920

Are the presynaptic membrane particles the calcium channels?

D W Pumplin, T S Reese, R Llinás.   

Abstract

The number of large intramembrane particles associated with sites of synaptic vesicle release at the squid giant synapse was determined and compared to the average maximal presynaptic calcium current in order to derive an estimate of the conductance each particle would have if it were a calcium channel. This value, 0.21 pS, compares favorably with conductances of calcium channels in other preparations, substantiating the idea that the large intramembrane particles, which are concentrated at "active zones," represent calcium channels.

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Year:  1981        PMID： 6273920      PMCID： PMC349226          DOI： 10.1073/pnas.78.11.7210

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  Conductance of the sodium channel in myelinated nerve fibres with modified sodium inactivation.

Authors:  F Conti; B Hille; B Neumcke; W Nonner; R Stämpfli
Journal:  J Physiol       Date:  1976-11       Impact factor: 5.182

2.  Single-channel currents recorded from membrane of denervated frog muscle fibres.

Authors:  E Neher; B Sakmann
Journal:  Nature       Date:  1976-04-29       Impact factor: 49.962

3.  Intramembranous particle distribution at the node of Ranvier and adjacent axolemma in myelinated axons of the frog brain.

Authors:  J Rosenbluth
Journal:  J Neurocytol       Date:  1976-12

4.  A quantitative description of membrane current and its application to conduction and excitation in nerve.

Authors:  A L HODGKIN; A F HUXLEY
Journal:  J Physiol       Date:  1952-08       Impact factor: 5.182

5.  Presynaptic calcium currents and their relation to synaptic transmission: voltage clamp study in squid giant synapse and theoretical model for the calcium gate.

Authors:  R Llinás; I Z Steinberg; K Walton
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205

Review 6.  The calcium conductance of neurons.

Authors:  A M Brown; N Akaike; K S Lee
Journal:  Ann N Y Acad Sci       Date:  1978-04-28       Impact factor: 5.691

7.  Functional changes in frog neuromuscular junctions studied with freeze-fracture.

Authors:  J E Heuser; T S Reese; D M Landis
Journal:  J Neurocytol       Date:  1974-03

8.  The units of calcium conduction in Helix neurones.

Authors:  N Akaike; H M Fishman; K S Lee; L E Moore; A M Brown
Journal:  Nature       Date:  1978-07-27       Impact factor: 49.962

9.  A study of synaptic transmission in the absence of nerve impulses.

Authors:  B Katz; R Miledi
Journal:  J Physiol       Date:  1967-09       Impact factor: 5.182

10.  Equilibrium potential for the postsynaptic response in the squid giant synapse.

Authors:  R Llinás; R W Joyner; C Nicholson
Journal:  J Gen Physiol       Date:  1974-11       Impact factor: 4.086
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  76 in total

1.  Pulsed laser imaging of Ca(2+) influx in a neuroendocrine terminal.

Authors:  T E Fisher; J M Fernandez
Journal:  J Neurosci       Date:  1999-09-01       Impact factor: 6.167

2.  Measurement of action potential-induced presynaptic calcium domains at a cultured neuromuscular junction.

Authors:  D A DiGregorio; A Peskoff; J L Vergara
Journal:  J Neurosci       Date:  1999-09-15       Impact factor: 6.167

3.  Effect of changes in action potential shape on calcium currents and transmitter release in a calyx-type synapse of the rat auditory brainstem.

Authors:  J G Borst; B Sakmann
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-02-28       Impact factor: 6.237

4.  Transmitter secretion in the frog neuromuscular synapse after prolonged exposure to calcium-free solutions.

Authors:  A L Zefirov; R D Mukhamedzyanov; M G Minlebaev; S Yu Cheranov; M M Abdrakhmanov; P N Grigor'ev
Journal:  Neurosci Behav Physiol       Date:  2003-07

5.  Calcium requirements for secretion in bovine chromaffin cells.

Authors:  G J Augustine; E Neher
Journal:  J Physiol       Date:  1992-05       Impact factor: 5.182

6.  Consequences of molecular-level Ca2+ channel and synaptic vesicle colocalization for the Ca2+ microdomain and neurotransmitter exocytosis: a monte carlo study.

Authors:  Vahid Shahrezaei; Kerry R Delaney
Journal:  Biophys J       Date:  2004-10       Impact factor: 4.033

Review 7.  Molecular mechanism of active zone organization at vertebrate neuromuscular junctions.

Authors:  Hiroshi Nishimune
Journal:  Mol Neurobiol       Date:  2011-12-02       Impact factor: 5.590

8.  Variable priming of a docked synaptic vesicle.

Authors:  Jae Hoon Jung; Joseph A Szule; Robert M Marshall; Uel J McMahan
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-08       Impact factor: 11.205

9.  Decreased calcium currents in motor nerve terminals of mice with Lambert-Eaton myasthenic syndrome.

Authors:  D O Smith; M W Conklin; P J Jensen; W D Atchison
Journal:  J Physiol       Date:  1995-08-15       Impact factor: 5.182

10.  Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells.

Authors:  I M Robinson; J M Finnegan; J R Monck; R M Wightman; J M Fernandez
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205
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