Literature DB >> 10212483

Effect of changes in action potential shape on calcium currents and transmitter release in a calyx-type synapse of the rat auditory brainstem.

J G Borst1, B Sakmann.   

Abstract

We studied the relation between the size of presynaptic calcium influx and transmitter release by making simultaneous voltage clamp recordings from presynaptic terminals, the calyces of Held and postsynaptic cells, the principal cells of the medical nucleus of the trapezoid body, in slices of the rat brainstem. Calyces were voltage clamped with different action potential waveforms. The amplitude of the excitatory postsynaptic currents depended supralinearly on the size of the calcium influx, in the absence of changes in the time-course of the calcium influx. This result is in agreement with the view that at this synapse most vesicles are released by the combined action of multiple calcium channels.

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Year:  1999        PMID： 10212483      PMCID： PMC1692496          DOI： 10.1098/rstb.1999.0386

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN： 0962-8436            Impact factor:   6.237


  54 in total

1.  Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses.

Authors:  L G Wu; R E Westenbroek; J G Borst; W A Catterall; B Sakmann
Journal:  J Neurosci       Date:  1999-01-15       Impact factor: 6.167

2.  Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom.

Authors:  B M Olivera; L J Cruz; V de Santos; G W LeCheminant; D Griffin; R Zeikus; J M McIntosh; R Galyean; J Varga; W R Gray
Journal:  Biochemistry       Date:  1987-04-21       Impact factor: 3.162

3.  Functional changes in frog neuromuscular junctions studied with freeze-fracture.

Authors:  J E Heuser; T S Reese; D M Landis
Journal:  J Neurocytol       Date:  1974-03

4.  Divalent cations differentially support transmitter release at the squid giant synapse.

Authors:  G J Augustine; R Eckert
Journal:  J Physiol       Date:  1984-01       Impact factor: 5.182

5.  Calcium entry and transmitter release at voltage-clamped nerve terminals of squid.

Authors:  G J Augustine; M P Charlton; S J Smith
Journal:  J Physiol       Date:  1985-10       Impact factor: 5.182

Review 6.  From vesicle docking to endocytosis: intermediate reactions of exocytosis.

Authors:  F E Schweizer; H Betz; G J Augustine
Journal:  Neuron       Date:  1995-04       Impact factor: 17.173

7.  Are the presynaptic membrane particles the calcium channels?

Authors:  D W Pumplin; T S Reese; R Llinás
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

8.  Calcium domains associated with individual channels can account for anomalous voltage relations of CA-dependent responses.

Authors:  J E Chad; R Eckert
Journal:  Biophys J       Date:  1984-05       Impact factor: 4.033

9.  Transmission by presynaptic spike-like depolarization in the squid giant synapse.

Authors:  R Llinás; M Sugimori; S M Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

10.  Co-operative action a calcium ions in transmitter release at the neuromuscular junction.

Authors:  F A Dodge; R Rahamimoff
Journal:  J Physiol       Date:  1967-11       Impact factor: 5.182
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  68 in total

1.  Specialized synapse-associated structures within the calyx of Held.

Authors:  K C Rowland; N K Irby; G A Spirou
Journal:  J Neurosci       Date:  2000-12-15       Impact factor: 6.167

2.  Properties of a model of Ca++-dependent vesicle pool dynamics and short term synaptic depression.

Authors:  S Weis; R Schneggenburger; E Neher
Journal:  Biophys J       Date:  1999-11       Impact factor: 4.033

3.  Calcium secretion coupling at calyx of Held governed by nonuniform channel-vesicle topography.

Authors:  Christoph J Meinrenken; J Gerard G Borst; Bert Sakmann
Journal:  J Neurosci       Date:  2002-03-01       Impact factor: 6.167

4.  Separation of presynaptic and postsynaptic contributions to depression by covariance analysis of successive EPSCs at the calyx of Held synapse.

Authors:  Volker Scheuss; Ralf Schneggenburger; Erwin Neher
Journal:  J Neurosci       Date:  2002-02-01       Impact factor: 6.167

5.  G-protein inhibition of N- and P/Q-type calcium channels: distinctive elementary mechanisms and their functional impact.

Authors:  H M Colecraft; D L Brody; D T Yue
Journal:  J Neurosci       Date:  2001-02-15       Impact factor: 6.167

6.  Heterogeneous presynaptic release probabilities: functional relevance for short-term plasticity.

Authors:  Julia Trommershäuser; Ralf Schneggenburger; Annette Zippelius; Erwin Neher
Journal:  Biophys J       Date:  2003-03       Impact factor: 4.033

7.  Sparse but highly efficient Kv3 outpace BKCa channels in action potential repolarization at hippocampal mossy fiber boutons.

Authors:  Henrik Alle; Hisahiko Kubota; Jörg R P Geiger
Journal:  J Neurosci       Date:  2011-06-01       Impact factor: 6.167

8.  Local routes revisited: the space and time dependence of the Ca2+ signal for phasic transmitter release at the rat calyx of Held.

Authors:  Christoph J Meinrenken; J Gerard G Borst; Bert Sakmann
Journal:  J Physiol       Date:  2003-01-31       Impact factor: 5.182

9.  Quantitative analysis of synaptic release at the photoreceptor synapse.

Authors:  Gabriel Duncan; Katalin Rabl; Ian Gemp; Ruth Heidelberger; Wallace B Thoreson
Journal:  Biophys J       Date:  2010-05-19       Impact factor: 4.033

10.  Septins regulate developmental switching from microdomain to nanodomain coupling of Ca(2+) influx to neurotransmitter release at a central synapse.

Authors:  Yi-Mei Yang; Michael J Fedchyshyn; Giovanbattista Grande; Jamila Aitoubah; Christopher W Tsang; Hong Xie; Cameron A Ackerley; William S Trimble; Lu-Yang Wang
Journal:  Neuron       Date:  2010-07-15       Impact factor: 17.173
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