Literature DB >> 6273747

Clustered arrangement of immunoglobulin lambda constant region genes in man.

P A Hieter, G F Hollis, S J Korsmeyer, T A Waldmann, P Leder.   

Abstract

The immunoglobulin lambda light chain locus of man contains six lambda-like genes arranged tandemly on a 50-kilobase segment of chromosomal DNA. THe sequences of three of these genes correspond to three known non-allelic lambda chain isotypes: Mcg, Ke-Oz- and Ke-Oz+. They surround a highly polymorphic and evidently unstable region that is repeatedly deleted when cloned in Escherichia coli. Three additional, but as yet unlinked, lambda-like sequences have also been cloned, suggesting that the lambda genes form an unexpectedly large family within the human genome.

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Year:  1981        PMID： 6273747     DOI： 10.1038/294536a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  109 in total

1.  Concanavalin A stimulation enhanced secondary VlambdaJlambda rearrangement in some human plasma B cells without up-regulation of recombination-activating gene expression and Vlambda germline transcription.

Authors:  H Haruta; H Tachibana; K Yamada
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2.  The mink gene for the lambda light immunoglobulin chain: characterization of cDNA and chromosomal localization.

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3.  Structure and expression of the human immunoglobulin lambda genes.

Authors:  T J Vasicek; P Leder
Journal:  J Exp Med       Date:  1990-08-01       Impact factor: 14.307

4.  Detection of immunoglobulin light-chain mRNA in lymphoid tissues using a practical in situ hybridization method.

Authors:  L M Weiss; L A Movahed; Y Y Chen; S S Shin; R M Stroup; N Bui; P Estess; J M Bindl
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5.  Delineating Rearrangements in Single Yeast Artificial Chromosomes by Quantitative DNA Fiber Mapping.

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Journal:  Open Genomics J       Date:  2009-10-09

6.  Molecular genetic analysis of lymphoid tumors arising after organ transplantation.

Authors:  J Locker; M Nalesnik
Journal:  Am J Pathol       Date:  1989-12       Impact factor: 4.307

7.  Genetics and expression of kappa-type light chains in Basilea rabbits.

Authors:  R G Mage; G O Young-Cooper; C B Alexander; A S Kelus
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

8.  Immunoglobulin mu-chain gene rearrangement in a patient with T cell acute lymphoblastic leukemia.

Authors:  K Ha; M Minden; N Hozumi; E W Gelfand
Journal:  J Clin Invest       Date:  1984-04       Impact factor: 14.808

9.  Human small-cell lung cancers show amplification and expression of the N-myc gene.

Authors:  M M Nau; B J Brooks; D N Carney; A F Gazdar; J F Battey; E A Sausville; J D Minna
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

10.  B cell lymphoma of the thymus and salivary gland.

Authors:  C Di Loreto; L Mariuzzi; A De Grassi; C A Beltrami
Journal:  J Clin Pathol       Date:  1996-07       Impact factor: 3.411
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