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Literature DB >> 6272123

Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids.

Abstract

Fusions between the mouse mammary tumour virus long terminal repeat and a mouse dihydrofolate reductase cDNA have been constructed in a SV40 vector. When these plasmids are transferred into recipient cells, the production of dihydrofolate reductase is regulated by glucocorticoid hormones. These results define a hormonally responsive region of the viral genome.

Entities: Disease Gene Species

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Year: 1981 PMID： 6272123 DOI： 10.1038/294228a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

145 in total

1. Mutations in the hormone regulatory element of mouse mammary tumor virus differentially affect the response to progestins, androgens, and glucocorticoids.

Authors: P L Gowland; E Buetti
Journal: Mol Cell Biol Date: 1989-09 Impact factor: 4.272

2. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

Authors: M Gossen; H Bujard
Journal: Proc Natl Acad Sci U S A Date: 1992-06-15 Impact factor: 11.205

3. Regulated expression of foreign genes in mammalian cells under the control of coliphage T3 RNA polymerase and lac repressor.

Authors: U Deuschle; R Pepperkok; F B Wang; T J Giordano; W T McAllister; W Ansorge; H Bujard
Journal: Proc Natl Acad Sci U S A Date: 1989-07 Impact factor: 11.205

10. Glucocorticoid and progestin receptors are differently involved in the cooperation with a structural element of the mouse mammary tumor virus promoter.

Authors: S Le Ricousse; F Gouilleux; D Fortin; V Joulin; H Richard-Foy
Journal: Proc Natl Acad Sci U S A Date: 1996-05-14 Impact factor: 11.205

Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids.

1. Mutations in the hormone regulatory element of mouse mammary tumor virus differentially affect the response to progestins, androgens, and glucocorticoids.

2. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

3. Regulated expression of foreign genes in mammalian cells under the control of coliphage T3 RNA polymerase and lac repressor.

4. The simian virus 40 small-t intron, present in many common expression vectors, leads to aberrant splicing.

5. Independent glucocorticoid induction and repression of two contiguous responsive genes.

6. Induction of human beta-interferon synthesis with poly(rI . rC) in mouse cells transfected with cloned cDNA plasmids.

7. Expression of abbreviated mouse dihydrofolate reductase genes in cultured hamster cells.

8. Myoblast transfer of human erythropoietin gene in a mouse model of renal failure.

9. Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

10. Glucocorticoid and progestin receptors are differently involved in the cooperation with a structural element of the mouse mammary tumor virus promoter.