Literature DB >> 6271054

Effect of acyclovir on latent herpes simplex virus infections in trigeminal ganglia of mice.

R J Klein, E DeStefano, A E Friedman-Kien, E Brady.   

Abstract

The inhibition by acyclovir of the in vitro reactivation of herpes simplex virus from latently infected ganglion explant cultures is dependent on the continuous presence of this drug. Administration of acyclovir subcutaneously, orally, or by continuous perfusion to mice with established latent infections did not eliminate latent virus from the trigeminal ganglia.

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Year:  1981        PMID： 6271054      PMCID： PMC181548          DOI： 10.1128/AAC.19.5.937

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  In vitro system for studying the efficacy of antiviral agents in preventing the reactivation of latent herpes simplex virus.

Authors:  C Wohlenberg; H Openshaw; A L Notkins
Journal:  Antimicrob Agents Chemother       Date:  1979-04       Impact factor: 5.191

2.  Efficacy of phosphonoacetic acid on herpes simplex virus infection of sensory ganglia.

Authors:  C R Wohlenberg; M A Walz; A L Notkins
Journal:  Infect Immun       Date:  1976-05       Impact factor: 3.441

3.  Orofacial herpes simplex virus infection in hairless mice: latent virus in trigeminal ganglia after topical antiviral treatment.

Authors:  R J Klein; A E Friedman-Kien; P B Yellin
Journal:  Infect Immun       Date:  1978-04       Impact factor: 3.441

4.  Herpes simplex virus skin infection in hairless mice: treatment with antiviral compounds.

Authors:  R J Klein; A E Friedman-Kien; E Brady
Journal:  Antimicrob Agents Chemother       Date:  1974-03       Impact factor: 5.191

5.  Herpetic ganglionic latency. Aciclovir and vidarabine therapy.

Authors:  D Pavan-Langston; N H Park; J H Lass
Journal:  Arch Ophthalmol       Date:  1979-08

6.  Effect of acyclovir on recurrence of herpes simplex skin lesions in mice.

Authors:  W A Blyth; D A Harbour; T J Hill
Journal:  J Gen Virol       Date:  1980-06       Impact factor: 3.891

7.  Effect of acycloguanosine treatment of acute and latent herpes simplex infections in mice.

Authors:  H J Field; S E Bell; G B Elion; A A Nash; P Wildy
Journal:  Antimicrob Agents Chemother       Date:  1979-04       Impact factor: 5.191
  7 in total
  9 in total

1.  Effects of 2,2'-O-cyclocytidine and acyclovir on latent herpes simplex virus in trigeminal ganglia of mice.

Authors:  W G Liu; Z J Chen; J Z Song; Z X Ma
Journal:  Antimicrob Agents Chemother       Date:  1986-02       Impact factor: 5.191

Review 2.  The pathogenesis of acute, latent and recurrent herpes simplex virus infections.

Authors:  R J Klein
Journal:  Arch Virol       Date:  1982       Impact factor: 2.574

3.  Effect of discontinuous acyclovir treatment on in vitro reactivation of herpes simplex virus from latently infected trigeminal ganglia.

Authors:  R J Klein; A E Friedman-Kien; E DeStefano
Journal:  Antimicrob Agents Chemother       Date:  1983-07       Impact factor: 5.191

4.  Effects of prolonged cultivation in the presence of acyclovir on recovery of latent herpes simplex virus from human trigeminal ganglia.

Authors:  M E Lewis; K G Warren; V M Jeffrey; D L Tyrrell
Journal:  Antimicrob Agents Chemother       Date:  1983-03       Impact factor: 5.191

Review 5.  Antiherpes drugs: promises and pitfalls.

Authors:  E de Clercq
Journal:  Eur J Clin Microbiol       Date:  1984-04       Impact factor: 3.267

6.  Alpha interferon and acyclovir treatment of herpes simplex virus in lymphoid cell cultures.

Authors:  S M Hammer; J C Kaplan; B R Lowe; M S Hirsch
Journal:  Antimicrob Agents Chemother       Date:  1982-04       Impact factor: 5.191

7.  Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on the acute local phase of herpes simplex virus-induced skin infections in mice and the establishment of latency.

Authors:  R J Klein; A E Friedman-Kien
Journal:  Antimicrob Agents Chemother       Date:  1985-05       Impact factor: 5.191

Review 8.  Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy.

Authors:  D M Richards; A A Carmine; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1983-11       Impact factor: 9.546

Review 9.  Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.

Authors:  J J O'Brien; D M Campoli-Richards
Journal:  Drugs       Date:  1989-03       Impact factor: 9.546
  9 in total

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