Literature DB >> 6270248

Genetic variation of neurotropic and non-neurotropic murine coronaviruses.

H Wege, J R Stephenson, M Koga, H Wege, V ter Meulen.   

Abstract

The murine coronavirus strains MHV JMH, MHV 1, MHV 2, MHV 3 and MHV A 59 were tested for their neurovirulence in weanling rats. The strain JHM was found to be highly neurovirulent for weanling rats, whereas the other strains were not, or only slightly, neurovirulent. MHV 1 caused no lesions in weanling rats. The other strains (MHV 2, MHV 3 and MVH A59) induced predominantly subclinical infections in weanling rats as demonstrated by an increase of antibodies and inflammatory lesions in the liver. Analysis of these strains by cross-neutralization revealed variable degrees of antigenic relationship between these viruses which were not related to their neurovirulence. However, when these strains were compared by analysing the T1-RNase-resistant oligonucleotides of virion RNA, the highly neurovirulent strain JHM was found to differ significantly in its nucleotide sequence from the other less-neurovirulent strains.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6270248     DOI： 10.1099/0022-1317-54-1-67

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  20 in total

1.  Protection from mouse hepatitis virus type 3-induced acute disease by an anti-nucleoprotein monoclonal antibody. Brief report.

Authors:  J Lecomte; V Cainelli-Gebara; G Mercier; S Mansour; P J Talbot; G Lussier; D Oth
Journal:  Arch Virol       Date:  1987       Impact factor: 2.574

2.  Sequence relationships between the genome and the intracellular RNA species 1, 3, 6, and 7 of mouse hepatitis virus strain A59.

Authors:  W J Spaan; P J Rottier; M C Horzinek; B A van der Zeijst
Journal:  J Virol       Date:  1982-05       Impact factor: 5.103

3.  Regulation of proinflammatory cytokine expression in primary mouse astrocytes by coronavirus infection.

Authors:  Dongdong Yu; Hongqing Zhu; Yin Liu; Jianzhong Cao; Xuming Zhang
Journal:  J Virol       Date:  2009-09-23       Impact factor: 5.103

4.  A comparative analysis of measles virus RNA by oligonucleotide fingerprinting.

Authors:  J R Stephenson; V ter Meulen
Journal:  Arch Virol       Date:  1982       Impact factor: 2.574

5.  Murine coronavirus spike protein determines the ability of the virus to replicate in the liver and cause hepatitis.

Authors:  S Navas; S H Seo; M M Chua; J Das Sarma; E Lavi; S T Hingley; S R Weiss
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

6.  The spike protein of murine coronavirus regulates viral genome transport from the cell surface to the endoplasmic reticulum during infection.

Authors:  Hongqing Zhu; Dongdong Yu; Xuming Zhang
Journal:  J Virol       Date:  2009-07-01       Impact factor: 5.103

7.  Alteration in oligonucleotide fingerprint patterns of the viral genome in poliovirus type 2 isolated from paralytic patients.

Authors:  T Yoneyama; A Hagiwara; M Hara; H Shimojo
Journal:  Infect Immun       Date:  1982-07       Impact factor: 3.441

8.  Antigenic relationships of murine coronaviruses.

Authors:  J C Childs; S A Stohlman; L Kingsford; R Russell
Journal:  Arch Virol       Date:  1983       Impact factor: 2.574

9.  Antigenic relationships of murine coronaviruses: analysis using monoclonal antibodies to JHM (MHV-4) virus.

Authors:  J O Fleming; S A Stohlman; R C Harmon; M M Lai; J A Frelinger; L P Weiner
Journal:  Virology       Date:  1983-12       Impact factor: 3.616

10.  Sequence analysis of the S gene of recombinant MHV-2/A59 coronaviruses reveals three candidate mutations associated with demyelination and hepatitis.

Authors:  J Das Sarma; L Fu; S T Hingley; M M Lai; E Lavi
Journal:  J Neurovirol       Date:  2001-10       Impact factor: 2.643
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.