Literature DB >> 2825619

Protection from mouse hepatitis virus type 3-induced acute disease by an anti-nucleoprotein monoclonal antibody. Brief report.

J Lecomte1, V Cainelli-Gebara, G Mercier, S Mansour, P J Talbot, G Lussier, D Oth.   

Abstract

Fusion of MHV-3-immune splenocytes from MHV-3-resistant A/J murine strain, with NS myeloma cells produced several hybridomas. Among eight hybridoma clones, the 1E7A4H1 clone secreted kappa IgG2a apparently directed against the nucleoprotein of the MHV-3 virion. The monoclonal antibody was able to neutralize the in vitro cytopathic effect of MHV-3 on cultured L2 cells, and was detected by indirect immunofluorescence on MHV-3-infected cultured YAC cells. In addition, it conferred a significant protection against MHV-3-induced acute disease, if injected intraperitoneally to C57BL/6 mice before inoculation with MHV-3.

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Year:  1987        PMID： 2825619      PMCID： PMC7086664          DOI： 10.1007/BF01310740

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  16 in total

1.  Prevalence of natural virus infections in laboratory mice and rats used in Canada.

Authors:  G Lussier; J P Descôteaux
Journal:  Lab Anim Sci       Date:  1986-04

2.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

3.  Hybridoma antibodies to the murine coronavirus JHM: characterization of epitopes on the peplomer protein (E2).

Authors:  H Wege; R Dörries; H Wege
Journal:  J Gen Virol       Date:  1984-11       Impact factor: 3.891

Review 4.  The biology and pathogenesis of coronaviruses.

Authors:  H Wege; S Siddell; V ter Meulen
Journal:  Curr Top Microbiol Immunol       Date:  1982       Impact factor: 4.291

5.  Protection against lethal viral infection by neutralizing and nonneutralizing monoclonal antibodies: distinct mechanisms of action in vivo.

Authors:  L Lefrancois
Journal:  J Virol       Date:  1984-07       Impact factor: 5.103

6.  Murine hepatitis virus-4 (strain JHM)-induced neurologic disease is modulated in vivo by monoclonal antibody.

Authors:  M J Buchmeier; H A Lewicki; P J Talbot; R L Knobler
Journal:  Virology       Date:  1984-01-30       Impact factor: 3.616

7.  Genetic variation of neurotropic and non-neurotropic murine coronaviruses.

Authors:  H Wege; J R Stephenson; M Koga; H Wege; V ter Meulen
Journal:  J Gen Virol       Date:  1981-05       Impact factor: 3.891

8.  Expression of influenza A virus internal antigens on the surface of infected P815 cells.

Authors:  J W Yewdell; E Frank; W Gerhard
Journal:  J Immunol       Date:  1981-05       Impact factor: 5.422

9.  Mouse hepatitis virus strain--related patterns of tissue tropism in suckling mice.

Authors:  S W Barthold; A L Smith
Journal:  Arch Virol       Date:  1984       Impact factor: 2.574

10.  Topographical mapping of epitopes on the glycoproteins of murine hepatitis virus-4 (strain JHM): correlation with biological activities.

Authors:  P J Talbot; A A Salmi; R L Knobler; M J Buchmeier
Journal:  Virology       Date:  1984-01-30       Impact factor: 3.616
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  36 in total

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Authors:  Steven A Rubin; Malen A Link; Christian J Sauder; Cheryl Zhang; Laurie Ngo; Bert K Rima; W Paul Duprex
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4.  Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis.

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5.  T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system.

Authors:  M A Sussman; R A Shubin; S Kyuwa; S A Stohlman
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6.  Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.

Authors:  S Kyuwa; M Cohen; G Nelson; S M Tahara; S A Stohlman
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7.  Enhanced virulence mediated by the murine coronavirus, mouse hepatitis virus strain JHM, is associated with a glycine at residue 310 of the spike glycoprotein.

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8.  MHC class II-restricted T-cell hybridomas recognizing the nucleocapsid protein of avian coronavirus IBV.

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Journal:  Immunology       Date:  1991-01       Impact factor: 7.397

9.  Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system.

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Journal:  J Virol       Date:  1995-02       Impact factor: 5.103

10.  Spread of a neurotropic coronavirus to spinal cord white matter via neurons and astrocytes.

Authors:  N Sun; S Perlman
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103
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