Literature DB >> 626988

Antitumor activity of N-trifuloroacetyladriamycin-14-valerate.

G Pratesi, A M Casazza, A Di Marco.   

Abstract

The antitumor activity and toxicity of N-trifluoroacetyladriamycin-14-valerate (AD 32) dissolved in 10% Tween 80 in distilled water were compared to those of adriamycin dissolved in distilled water in 10% Tween 80 in distilled water, in mice bearing L1210 leukemia, P388 leukemia, Gross leukemia, and solid Sarcoma 180. Treatments were performed ip or iv according to different schedules. The antitumor-activity of AD 32 was not superior to that of adriamycin. The antitumor activity of adriamycin dissolved in aqueous solution of Tween 80 was higher than that of adriamycin dissolved in distilled water after after iv treatment.

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Year:  1978        PMID： 626988

Source DB:  PubMed          Journal:  Cancer Treat Rep        ISSN： 0361-5960


  5 in total

1.  Serum and tissue levels of platinum after cisplatinum instillation of the rat bladder.

Authors:  H A Wagner; G Groebe; U Engelmann
Journal:  Urol Res       Date:  1988

2.  Intravesical chemotherapy: combination with Tween 80 increases cytotoxicity in vitro.

Authors:  C N Parris; J R Masters; M C Walker; B Newman; P Riddle; P English
Journal:  Urol Res       Date:  1987

3.  A survey of the anthracycline derivatives in hematology.

Authors:  C Jacquillat; M Weil; M F Auclerc; J Maral; G Schaison; M Boiron; J Bernard
Journal:  Cancer Chemother Pharmacol       Date:  1979       Impact factor: 3.333

4.  Radioactive species in rat urines and tissues after [14C] AD 32 administration.

Authors:  G Zini; G P Vicario; M Lazzati; F Arcamone
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

5.  Permeability of the rat bladder to Cisplatinum under different conditions: comparison with Mitomycin C and Adriamycin.

Authors:  U Engelmann; G Oelsner; R A Bürger; H Wagner
Journal:  Urol Res       Date:  1983
  5 in total

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