Literature DB >> 6269490

Efficacy of acyclovir against mouse cytomegalovirus in vivo.

J R Wingard, W J Bender, R Saral, W H Burns.   

Abstract

Acyclovir reduced mortality and organ virus titers in mice inoculated intraperitoneally with 10 50% lethal doses of mouse cytomegalovirus. This susceptibility to acyclovir of a herpesvirus which lacks thymidine kinase is surprising. Alternative phosphorylating enzymes may account for this susceptibility.

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Year:  1981        PMID： 6269490      PMCID： PMC181681          DOI： 10.1128/AAC.20.2.275

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Replication of mouse cytomegalovirus in thymidine kinase-deficient mouse cells.

Authors:  Y Eizuru; Y Minamishima; A Hirano; T Kurimura
Journal:  Microbiol Immunol       Date:  1978       Impact factor: 1.955

2.  Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

Authors:  J A Fyfe; P M Keller; P A Furman; R L Miller; G B Elion
Journal:  J Biol Chem       Date:  1978-12-25       Impact factor: 5.157

3.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

4.  9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.

Authors:  H J Schaeffer; L Beauchamp; P de Miranda; G B Elion; D J Bauer; P Collins
Journal:  Nature       Date:  1978-04-13       Impact factor: 49.962

5.  Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by acycloguanosine.

Authors:  R J Klein; A E Friedman-Kien; E DeStefano
Journal:  Antimicrob Agents Chemother       Date:  1979-05       Impact factor: 5.191

6.  Growth inhibition by acycloguanosine of herpesviruses isolated from human infections.

Authors:  C S Crumpacker; L E Schnipper; J A Zaia; M J Levin
Journal:  Antimicrob Agents Chemother       Date:  1979-05       Impact factor: 5.191

7.  Effect of cytosine arabinoside and 5-iodo-2'-deoxyuridine on a cytomegalovirus infection in newborn mice.

Authors:  D K Kelsey; E R Kern; J C Overall; L A Glasgow
Journal:  Antimicrob Agents Chemother       Date:  1976-03       Impact factor: 5.191

8.  Thymidine kinase activity in mouse 3T3 cells infected by murine cytomegalovirus (MCV).

Authors:  M T Muller; J B Hudson
Journal:  Virology       Date:  1977-07-15       Impact factor: 3.616

9.  Therapy of experimental herpes simplex encephalitis with aciclovir in mice.

Authors:  N H Park; D Pavan-Langston; S L McLean; D M Albert
Journal:  Antimicrob Agents Chemother       Date:  1979-06       Impact factor: 5.191

10.  Effect of acycloguanosine treatment of acute and latent herpes simplex infections in mice.

Authors:  H J Field; S E Bell; G B Elion; A A Nash; P Wildy
Journal:  Antimicrob Agents Chemother       Date:  1979-04       Impact factor: 5.191
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  4 in total

1.  Antiviral T cell response triggers cytomegalovirus hepatitis in mice.

Authors:  Devon Livingston-Rosanoff; Lisa P Daley-Bauer; AnaPatricia Garcia; A Louise McCormick; Jing Huang; Edward S Mocarski
Journal:  J Virol       Date:  2012-09-19       Impact factor: 5.103

2.  Genetic analysis of the susceptibility of mouse cytomegalovirus to acyclovir.

Authors:  G R Sandford; J R Wingard; J W Simons; S P Staal; R Saral; W H Burns
Journal:  J Virol       Date:  1985-04       Impact factor: 5.103

3.  Inhibition of murine cytomegalovirus lung infection and interstitial pneumonitis by acyclovir and 9-(1,3-dihydroxy-2-propoxymethyl)guanine.

Authors:  J D Shanley; J Morningstar; M C Jordan
Journal:  Antimicrob Agents Chemother       Date:  1985-08       Impact factor: 5.191

4.  Therapeutic effect of acyclovir (ZoviraxTM) on the pathogenesis of chronic murine cytomegalovirus infection in the immunodeficient nude mouse.

Authors:  P Carthew
Journal:  Br J Exp Pathol       Date:  1982-12
  4 in total

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