Literature DB >> 6269001

Quercetin inhibits tyrosine phosphorylation by the cyclic nucleotide-independent, transforming protein kinase, pp60src.

H Glossmann, P Presek, E Eigenbrodt.   

Abstract

The bioflavonoid quercetin is a potent inhibitor of a cyclic nucleotide-independent, tumor virus-coded protein kinase which phosphorylates tyrosine residues and acts as a cellular transforming protein. Half-maximal inhibition of the protein kinase occurred at 3-4 microM quercetin whereas rutin was much less effective. The finding, that quercetin inhibits a cyclic nucleotide-independent protein kinase activity, may provide clues to the diverse pharmacological effects of the bioflavonoids.

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Year:  1981        PMID： 6269001     DOI： 10.1007/bf00506266

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  10 in total

1.  Association of the src-gene product of Rous sarcoma virus with a pyruvate-kinase inactivation factor.

Authors:  H Glossmann; P Presek; E Eigenbrodt
Journal:  Mol Cell Endocrinol       Date:  1981-07       Impact factor: 4.102

2.  The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine.

Authors:  A D Levinson; H Oppermann; H E Varmus; J M Bishop
Journal:  J Biol Chem       Date:  1980-12-25       Impact factor: 5.157

3.  Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.

Authors:  T Hunter; B M Sefton
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

4.  Similarities between a phosphoprotein (pp60src)-associated protein kinase of Rous sarcoma virus and a cyclic adenosine 3':5'-monophosphate-independent protein kinase that phosphorylates pyruvate kinase type M2.

Authors:  P Presek; H Glossmann; E Eigenbrodt; W Schoner; H Rübsamen; R R Friis; H Bauer
Journal:  Cancer Res       Date:  1980-05       Impact factor: 12.701

5.  The effect of flavonoids on aerobic glycolysis and growth of tumor cells.

Authors:  E M Suolinna; R N Buchsbaum; E Racker
Journal:  Cancer Res       Date:  1975-07       Impact factor: 12.701

6.  High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase.

Authors:  E Bustamante; P L Pedersen
Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205

7.  Reconstitution of the Na+K+ pump of Ehrlich ascites tumor and enhancement of efficiency by quercetin.

Authors:  M Spector; S O'Neal; E Racker
Journal:  J Biol Chem       Date:  1980-06-25       Impact factor: 5.157

8.  Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosine.

Authors:  M S Collett; A F Purchio; R L Erikson
Journal:  Nature       Date:  1980-05-15       Impact factor: 49.962

9.  Inhibition of casein kinase II by heparin.

Authors:  G M Hathaway; T H Lubben; J A Traugh
Journal:  J Biol Chem       Date:  1980-09-10       Impact factor: 5.157

10.  Quercetin interaction with the (Ca2+ + Mg2+)-ATPase of sarcoplasmic reticulum.

Authors:  V Shoshan; D H MacLennan
Journal:  J Biol Chem       Date:  1981-01-25       Impact factor: 5.157
  10 in total
  12 in total

Review 1.  Ten things you should know about protein kinases: IUPHAR Review 14.

Authors:  Doriano Fabbro; Sandra W Cowan-Jacob; Henrik Moebitz
Journal:  Br J Pharmacol       Date:  2015-03-24       Impact factor: 8.739

2.  Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays.

Authors:  Katrin Tiemann; Carolina Garri; Jeffrey Wang; Lauren Clarke; Kian Kani
Journal:  J Vis Exp       Date:  2018-09-19       Impact factor: 1.355

Review 3.  Wine as a biological fluid: history, production, and role in disease prevention.

Authors:  G J Soleas; E P Diamandis; D M Goldberg
Journal:  J Clin Lab Anal       Date:  1997       Impact factor: 2.352

4.  Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus.

Authors:  Y Uehara; M Hori; T Takeuchi; H Umezawa
Journal:  Mol Cell Biol       Date:  1986-06       Impact factor: 4.272

5.  Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor.

Authors:  Y T Huang; J J Hwang; P P Lee; F C Ke; J H Huang; C J Huang; C Kandaswami; E Middleton; M T Lee
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

6.  The flavonoid scaffold as a template for the design of modulators of the vascular Ca(v) 1.2 channels.

Authors:  S Saponara; E Carosati; P Mugnai; G Sgaragli; F Fusi
Journal:  Br J Pharmacol       Date:  2011-11       Impact factor: 8.739

Review 7.  Flavonoid compounds in maintenance of prostate health and prevention and treatment of cancer.

Authors:  David M Brown; Graham E Kelly; Alan J Husband
Journal:  Mol Biotechnol       Date:  2005-07       Impact factor: 2.695

8.  Dietary polyphenols identified as intracellular protein kinase A inhibitors.

Authors:  Jan Øivind Moskaug; Grethe I Borge; Anne M Fagervoll; Ingvild Paur; Harald Carlsen; Rune Blomhoff
Journal:  Eur J Nutr       Date:  2008-10-24       Impact factor: 5.614

9.  Biochemical characteristics of cytosolic and particulate forms of protein tyrosine kinases from N-methyl-N-nitrosourea (MNU)-induced rat mammary carcinoma.

Authors:  A K Srivastava; J C Chiasson; J L Chiasson; A Lacroix; L Windisch
Journal:  Mol Cell Biochem       Date:  1991-07-24       Impact factor: 3.396

10.  Modulation of the effect of histamine-releasing lymphokine on human basophils.

Authors:  I C Ezeamuzie; E S Assem
Journal:  Agents Actions       Date:  1984-04
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