Literature DB >> 43080

Slow-reacting substance of anaphylaxis: studies on purification and characterisation.

H R Morris, G W Taylor, P J Piper, J R Tippins.   

Abstract

We have demonstrated the role of arachidonic acid and lipoxygenase in the genesis of SRS-A and the possible role of lipoxygenases in its metabolism. SRS-A has been purified in microgram quantities together with closely related material. We have identified 5,12 di-hydroxy-6, 8, 10, 14 eicosatetranenoic acid released by antigen challenge, and which we feel is related to SRS-A. Further structural work is in progress.

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Year:  1979        PMID: 43080     DOI: 10.1007/978-3-0348-7232-4_3

Source DB:  PubMed          Journal:  Agents Actions Suppl        ISSN: 0379-0363


  8 in total

1.  Modulation of the contractile activity of the guinea-pig lung parenchymal strip by exogenous 5,8,11,14,17-eicosapentaenoic acid.

Authors:  T Simmet; J Aissa; D Sutter; H Juan; B A Peskar
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-06       Impact factor: 3.000

Review 2.  Leukotrienes: a new approach to the biochemistry of hypersensitivity.

Authors:  P Sirois; P Borgeat
Journal:  Surv Immunol Res       Date:  1982

3.  Detection of sputum eicosanoids in cystic fibrosis and in normal saliva by bioassay and radioimmunoassay.

Authors:  J T Zakrzewski; N C Barnes; P J Piper; J F Costello
Journal:  Br J Clin Pharmacol       Date:  1987-01       Impact factor: 4.335

4.  Slow-reacting substances and their formation by a lipoxygenase pathway.

Authors:  P J Piper; M N Samhoun; J R Tippins; H R Morris; G W Taylor
Journal:  Agents Actions       Date:  1980-12

5.  Stimulation of arachidonic acid metabolism and generation of thromboxane A2 by leukotrienes B4, C4 and D4 in guinea-pig lung in vitro.

Authors:  P J Piper; M N Samhoun
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

6.  Effect of exogenous 5,8,11,14,17-eicosapentaenoic acid on cardiac anaphylaxis.

Authors:  H Juan; B A Peskar; T Simmet
Journal:  Br J Pharmacol       Date:  1987-02       Impact factor: 8.739

7.  Leukotriene B4: a mediator of vascular permeability.

Authors:  M A Bray; F M Cunningham; A W Ford-Hutchinson; M J Smith
Journal:  Br J Pharmacol       Date:  1981-03       Impact factor: 8.739

Review 8.  Leukotriene B4 and neutrophil function: a review.

Authors:  A W Ford-Hutchinson
Journal:  J R Soc Med       Date:  1981-11       Impact factor: 18.000

  8 in total

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