Literature DB >> 6265100

The structure of the human histone genes: clustered but not tandemly repeated.

N Heintz, M Zernik, R G Roeder.   

Abstract

We have isolated five clones containing human histone genes from a human genomic DNA library, using a cloned X. laevis histone H4 cDNA probe (pX1ch4). Each genomic clone has been mapped and the locations of the histone genes have been determined by blot hybridization and hybridization-selection of human histone mRNA. In contrast to the organization of previously characterized histone genes, the human histone genes are clustered in the genome but are not arranged into recognizable repeating units. The extreme lack of organization of the human histone genes may reflect the diminished requirement for rapid synthesis of large quantities of histone proteins during mammalian early development.

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Year:  1981        PMID： 6265100     DOI： 10.1016/0092-8674(81)90092-1

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  68 in total

1.  A comprehensive compilation and alignment of histones and histone genes.

Authors:  D Wells; C McBride
Journal:  Nucleic Acids Res       Date:  1989       Impact factor: 16.971

2.  Overlapping and CpG methylation-sensitive protein-DNA interactions at the histone H4 transcriptional cell cycle domain: distinctions between two human H4 gene promoters.

Authors:  A J van Wijnen; F M van den Ent; J B Lian; J L Stein; G S Stein
Journal:  Mol Cell Biol       Date:  1992-07       Impact factor: 4.272

3.  Analysis of herpes simplex virus-induced mRNA destabilizing activity using an in vitro mRNA decay system.

Authors:  C M Sorenson; P A Hart; J Ross
Journal:  Nucleic Acids Res       Date:  1991-08-25       Impact factor: 16.971

4.  Isolation and characterization of a Drosophila hydei histone DNA repeat unit.

Authors:  H Kremer; W Hennig
Journal:  Nucleic Acids Res       Date:  1990-03-25       Impact factor: 16.971

5.  Replacement variant histone genes contain intervening sequences.

Authors:  D Brush; J B Dodgson; O R Choi; P W Stevens; J D Engel
Journal:  Mol Cell Biol       Date:  1985-06       Impact factor: 4.272

6.  The uni chromosome of Chlamydomonas: histone genes and nucleosome structure.

Authors:  Z Walther; J L Hall
Journal:  Nucleic Acids Res       Date:  1995-09-25       Impact factor: 16.971

7.  Three organizations of human DNA.

Authors:  D Strayer; N Heintz; R Roeder; D Gillespie
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

8.  Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation.

Authors:  D B Sittman; R A Graves; W F Marzluff
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

9.  Replication origins and a sequence involved in coordinate induction of the immediate-early gene family are conserved in an intergenic region of herpes simplex virus.

Authors:  J L Whitton; J B Clements
Journal:  Nucleic Acids Res       Date:  1984-02-24       Impact factor: 16.971

10.  Transcription of a cloned Xenopus laevis H4 histone gene in the homologous frog oocyte system depends on an evolutionary conserved sequence motif in the -50 region.

Authors:  R G Clerc; P Bucher; K Strub; M L Birnstiel
Journal:  Nucleic Acids Res       Date:  1983-12-20       Impact factor: 16.971
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