Literature DB >> 6264165

Analysis of the myeloproliferative sarcoma virus genome: limited changes in the prototype lead to altered target cell specificity.

I B Pragnell, A Fusco, C Arbuthnott, F Smadja-Joffe, B Klein, C Jasmin, W Ostertag.   

Abstract

The myeloproliferative sarcoma virus (MPSV) derived from Moloney sarcoma virus (MSV-Mol) is a unique sarcoma virus which causes expansion of the hematopoietic stem cell compartment as well as the erythroid and myeloid cell lineages. MPSV also induces spleen focus formation in adult mice as do Friend and Rauscher viruses. Analysis of the MPSV genome on methyl mercury gels showed that the genome size is 7.0 kilobases, which is larger than the defective genome of any known MSV-Mol isolate. Hybridization analysis with specific cDNA probes showed that MPSV is a modified sarcoma virus with no sequences in the unique region of the defective sarcoma genome related to unique Friend virus sequences. The only viral sequences in the defective genome other than helper virus-related sequences are derived from the Moloney sarcoma virus genome with no new cellular sequences added. There was no evidence for induction of xenotropic virus sequences in MPSV-infected spleens of DBA/2J mice, indicating that spleen focus formation can be obtained by different mechanisms.

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Year:  1981        PMID： 6264165      PMCID： PMC171233     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  Direct transformation of 3T3 cells by Abelson murine leukaemia virus.

Authors:  C D Scher; R Siegler
Journal:  Nature       Date:  1975-02-27       Impact factor: 49.962

2.  DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.

Authors:  D Stehelin; H E Varmus; J M Bishop; P K Vogt
Journal:  Nature       Date:  1976-03-11       Impact factor: 49.962

3.  Murine sarcoma viruses: the helper-independence reported for a Moloney variant is unconfirmed; distinct strains differ in the size of their RNAs.

Authors:  J Maisel; D Dina; P Duesberg
Journal:  Virology       Date:  1977-01       Impact factor: 3.616

4.  Size, subunit composition, and secondary structure of the Friend virus genome.

Authors:  S Dube; H J Kung; W Bender; N Davidson; W Ostertag
Journal:  J Virol       Date:  1976-10       Impact factor: 5.103

5.  Biological, pathological and physical characterization of a possible variant of a murine sarcoma virus (Moloney).

Authors:  M A Chirigos; D Scott; W Turner; K Perk
Journal:  Int J Cancer       Date:  1968-03-15       Impact factor: 7.396

Review 6.  Transforming genes of retroviruses.

Authors:  P H Duesberg
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1980

7.  Rat insulin genes: construction of plasmids containing the coding sequences.

Authors:  A Ullrich; J Shine; J Chirgwin; R Pictet; E Tischer; W J Rutter; H M Goodman
Journal:  Science       Date:  1977-06-17       Impact factor: 47.728

8.  Friend strain of spleen focus-forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus.

Authors:  D H Troxler; J K Boyars; W P Parks; E M Scolnick
Journal:  J Virol       Date:  1977-05       Impact factor: 5.103

9.  Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus.

Authors:  E M Scolnick; E Rands; D Williams; W P Parks
Journal:  J Virol       Date:  1973-09       Impact factor: 5.103

10.  Nucleotide sequences in mouse DNA and RNA specific for Moloney sarcoma virus.

Authors:  A E Frankel; P J Fischinger
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205
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  12 in total

1.  The myeloproliferative sarcoma virus causes transformation or erythroid progenitor cells in vitro.

Authors:  W D Hankins; T A Kost; I B Pragnell
Journal:  Mol Cell Biol       Date:  1982-02       Impact factor: 4.272

2.  Long terminal repeat sequences impart hematopoietic transformation properties to the myeloproliferative sarcoma virus.

Authors:  C Stocking; R Kollek; U Bergholz; W Ostertag
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

3.  A temperature-sensitive mutant of the myeloproliferative sarcoma virus, altered by a point mutation in the mos oncogene, has been modified as a selectable retroviral vector.

Authors:  J Friel; C Stocking; A Stacey; W Ostertag
Journal:  J Virol       Date:  1987-03       Impact factor: 5.103

4.  The malignant histiocytosis sarcoma virus, a recombinant of Harvey murine sarcoma virus and Friend mink cell focus-forming virus, has acquired myeloid transformation specificity by alterations in the long terminal repeat.

Authors:  J Friel; D Hughes; I Pragnell; C Stocking; C Laker; J Nowock; W Ostertag; R A Padua
Journal:  J Virol       Date:  1990-01       Impact factor: 5.103

5.  Comparison of myeloproliferative sarcoma virus with Moloney murine sarcoma virus variants by nucleotide sequencing and heteroduplex analysis.

Authors:  A Stacey; C Arbuthnott; R Kollek; L Coggins; W Ostertag
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

6.  Molecular cloning and characterization of a leukemia-inducing myeloproliferative sarcoma virus and two of its temperature-sensitive mutants.

Authors:  R Kollek; C Stocking; F Smadja-Joffe; W Ostertag
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

7.  Lack of retrovirus gene expression in somatic cell hybrids of friend cells and teratocarcinoma cells with a teratocarcinoma phenotype.

Authors:  W Asche; G Colletta; G Warnecke; P Nobis; S Pennie; R M King; W Ostertag
Journal:  Mol Cell Biol       Date:  1984-05       Impact factor: 4.272

8.  Action of temperature-sensitive mutants of myeloproliferative sarcoma virus suggests that fibroblast-transforming and hematopoietic transforming viral properties are related.

Authors:  W Ostertag; M Freshney; K Vehmeyer; C Jasmin; G Rutter
Journal:  J Virol       Date:  1984-01       Impact factor: 5.103

9.  A mos oncogene-containing retrovirus, myeloproliferative sarcoma virus, transforms rat thyroid epithelial cells and irreversibly blocks their differentiation pattern.

Authors:  A Fusco; G Portella; P P Di Fiore; M T Berlingieri; R Di Lauro; A B Schneider; G Vecchio
Journal:  J Virol       Date:  1985-10       Impact factor: 5.103

10.  Recombinational junctions of variants of Moloney murine sarcoma virus: generation and divergence of a mammalian transforming gene.

Authors:  D J Donoghue; T Hunter
Journal:  J Virol       Date:  1983-02       Impact factor: 5.103
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