Literature DB >> 6263681

Quantitative changes in beta-adrenergic responses of isolated atria from hyper- and hypothyroid rats.

H P Rub, H Thommen, H Porzig.   

Abstract

Concentration-response curves for the chronotropic and inotropic effects of isoprenaline, in the absence and presence of propranolol, were obtained on heart atria isolated from normo- or dysthyroid rats. Hyperthyroidism increased the chronotropic potency and efficacy of the beta-adrenergic agonist. The results are compatible with the view that thyroid hormone increases the density of functional beta-adrenoceptors in cardiac pacemaker tissue.

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Year:  1981        PMID： 6263681     DOI： 10.1007/bf01959885

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  16 in total

1.  On spare beta-adrenoceptors of inotropic effect of catecholamines in kitten ventricle.

Authors:  A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-11       Impact factor: 3.000

2.  Effect of L-triiodothyronine on (--)3H-dihydroalprenolol binding and cyclic AMP response to (--)adrenaline in cultured heart cells.

Authors:  J S Tsai; A Chen
Journal:  Nature       Date:  1978-09-14       Impact factor: 49.962

3.  beta-Adrenergic receptors in rat heart: effects of thyroidectomy.

Authors:  S P Banerjee; L S Kung
Journal:  Eur J Pharmacol       Date:  1977-05-15       Impact factor: 4.432

4.  Influence of thyroid hormone on the positive inotropic effects mediated by alpha- and beta-adrenoceptors in isolated guinea pig atria and rabbit papillary muscles.

Authors:  H Hashimoto; M Nakashima
Journal:  Eur J Pharmacol       Date:  1978-08-15       Impact factor: 4.432

5.  Effects of isoproterenol on isolated heart preparations from normal and hyperthyroid rats.

Authors:  P A Longhurst; J H McNeill
Journal:  Proc West Pharmacol Soc       Date:  1979

6.  High efficiency coupling between beta-adrenergic receptors and cardiac contractility: direct evidence for "spare" beta-adrenergic receptors.

Authors:  J C Venter
Journal:  Mol Pharmacol       Date:  1979-09       Impact factor: 4.436

7.  Adrenergic responses in atria from euthyroid and hypothyroid rats.

Authors:  J H McNeill; W W Simpson
Journal:  Proc West Pharmacol Soc       Date:  1979

8.  Thyroid hormone regulation of beta-adrenergic receptor number.

Authors:  L T Williams; R J Lefkowitz; A M Watanabe; D R Hathaway; H R Besch
Journal:  J Biol Chem       Date:  1977-04-25       Impact factor: 5.157

9.  Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism.

Authors:  H J Schümann; E Borowski; G Gross
Journal:  Eur J Pharmacol       Date:  1979-06       Impact factor: 4.432

10.  Catecholamine sensitivity in hyperthyroidism and hypothyroidism.

Authors:  D G McDevitt; J G Riddell; D R Hadden; D A Montgomery
Journal:  Br J Clin Pharmacol       Date:  1978-10       Impact factor: 4.335
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  3 in total

1.  The effects of thyroxine treatment of rats on neuronal and extraneuronal uptake and metabolism of catecholamines in the heart.

Authors:  L J Bryan; S R O'Donnell; A M Williams
Journal:  Br J Pharmacol       Date:  1986-02       Impact factor: 8.739

2.  Interactions of beta-adrenoceptor antagonists and thyroid hormones in the control of heart rate in the dog.

Authors:  M C Allely; A Ungar
Journal:  Br J Pharmacol       Date:  1985-10       Impact factor: 8.739

3.  Thyroid-dependent alterations of myocardial adrenoceptors and adrenoceptor-mediated responses in the rat.

Authors:  G Gross; I Lues
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-06       Impact factor: 3.000
  3 in total

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