Literature DB >> 6262851

Clonidine-induced hyperphagia in monkeys: evidence for alpha 2-noradrenergic receptor mediation.

R F Schlemmer, J K Elder, R C Casper, J M Davis.   

Abstract

The mechanism of clonidine-induced hyperphagia and weight gain in monkeys was studied in 11 Stumptail macaques. Clonidine induced a significant increase in food intake over baseline levels and a significant weight gain after the 3-day treatment period. Both changes induced by clonidine were antagonized by the alpha 2-noradrenergic antagonist yohimbine, but not by prazosin, an alpha 1-noradrenergic antagonist. These results suggest that clonidine-induced hyperphagia and weight gain in monkeys are mediated through alpha 2-noradrenergic receptors.

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Year:  1981        PMID： 6262851     DOI： 10.1007/bf00431113

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  9 in total

1.  Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors.

Authors:  J C Doxey; C F Smith; J M Walker
Journal:  Br J Pharmacol       Date:  1977-05       Impact factor: 8.739

Review 2.  Regulation of noradrenaline release by presynaptic receptor systems.

Authors:  K Starke
Journal:  Rev Physiol Biochem Pharmacol       Date:  1977       Impact factor: 5.545

3.  Further evidence for alpha-2 adrenergic receptor mediated inhibition of prolactin secretion: the effect of yohimbine.

Authors:  M S Gold; R K Donabedian; D E Redmond
Journal:  Psychoneuroendocrinology       Date:  1978-10       Impact factor: 4.905

4.  Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine.

Authors:  K Starke; E Borowski; T Endo
Journal:  Eur J Pharmacol       Date:  1975-12       Impact factor: 4.432

5.  Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents.

Authors:  N E Andén; M Grabowska; U Strömbom
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

6.  Catecholamine receptors on locus coeruleus neurons: pharmacological characterization.

Authors:  J M Cedarbaum; G K Aghajanian
Journal:  Eur J Pharmacol       Date:  1977-08-15       Impact factor: 4.432

7.  Hyperphagia and hyperdipsia after locus coeruleus lesions in the stumptailed monkey.

Authors:  D E Redmond; Y H Huang; D R Snyder; J W Maas; J Baulu
Journal:  Life Sci       Date:  1977-05-01       Impact factor: 5.037

8.  Clonidine induced hyperphagia and weight gain in monkeys.

Authors:  R F Schlemmer; R C Casper; N Narasimhachari; J M Davis
Journal:  Psychopharmacology (Berl)       Date:  1979-03-22       Impact factor: 4.530

9.  The determination of a brain arteriovenous difference for 3-methoxy-4-hydroxyphenethyleneglycol (MHPG).

Authors:  J W Maas; S E Hattox; D H Landis; R H Roth
Journal:  Brain Res       Date:  1976-12-10       Impact factor: 3.252
  9 in total
  1 in total

1.  An analysis of the effects of systemically administered clonidine on the food and water intake of rats.

Authors:  D J Sanger
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739
  1 in total

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