| Literature DB >> 6261269 |
B Uran, F C Tulunay, I H Ayhan, E Ulkü, S Kaymakçalan.
Abstract
The administration of 0.3-40 mg/kg delta 9-tetrahydrocannabinol (THC) produced a dose-dependent hypothermia in rats. The maximal hypothermic effect was obtained with the dose of 2.5 mg/kg of THC. When the same doses of THC were repeated on days 2 and 3, tolerance to the hypothermic effect of THC was apparent. Doses of THC higher than 2.5 mg/kg induced a significant and dose-dependent tolerance after the first administration whereas with the lower doses, tolerance was only apparent after the second injection. The possible mechanism of these effects of THC is discussed.Entities:
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Year: 1980 PMID： 6261269 DOI： 10.1159/000137458
Source DB: PubMed Journal: Pharmacology ISSN： 0031-7012 Impact factor: 2.547