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Literature DB >> 6255481

Avermectin B1a, a paralyzing anthelmintic that affects interneurons and inhibitory motoneurons in Ascaris.

I S Kass, C C Wang, J P Walrond, A O Stretton.

Abstract

Avermectin B1a (AVM) is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis. Using selective stimulation techniques, we have shown that AVM blocks transmission between interneuron(s) and excitatory motorneurons in the ventral nerve cord of Ascaris. It also inhibits transmissin between inhibitory motoneurons and muscle but has little effect on excitatory neuromuscular transmission. Picrotoxin can reverse the AVM-induced block of interneuron-excitatory motoneuron transmission but has no effect on the inhibitory motoneuronal synapse in either the presence or absence of AVM. Our results provide an explanation of how AVM may cause paralysis of nematodes.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1980 PMID： 6255481 PMCID： PMC350245 DOI： 10.1073/pnas.77.10.6211

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

12 in total

1. Structure and physiological activity of the motoneurons of the nematode Ascaris.

Authors: A O Stretton; R M Fishpool; E Southgate; J E Donmoyer; J P Walrond; J E Moses; I S Kass
Journal: Proc Natl Acad Sci U S A Date: 1978-07 Impact factor: 11.205

2. Avermectins, new family of potent anthelmintic agents: isolation and chromatographic properties.

Authors: T W Miller; L Chaiet; D J Cole; L J Cole; J E Flor; R T Goegelman; V P Gullo; H Joshua; A J Kempf; W R Krellwitz; R L Monaghan; R E Ormond; K E Wilson; G Albers-Schönberg; I Putter
Journal: Antimicrob Agents Chemother Date: 1979-03 Impact factor: 5.191

Review 3. The biochemistry of helminths.

Authors: T von Brand
Journal: Z Parasitenkd Date: 1974

4. Some pharmacodynamic effects of the nematocides: methyridine, tetramisole and pyrantel.

Authors: P Eyre
Journal: J Pharm Pharmacol Date: 1970-01 Impact factor: 3.765

5. Insecticidal activity of the anti-parasitic avermectins.

Authors: D A Ostlind; S Cifelli; R Lang
Journal: Vet Rec Date: 1979-08-25 Impact factor: 2.695

6. Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance.

Authors: L C Fritz; C C Wang; A Gorio
Journal: Proc Natl Acad Sci U S A Date: 1979-04 Impact factor: 11.205

7. Inhibitory action of gamma-aminobutyric acid (GABA) on Ascaris muscle.

Authors: J Del Castillo; W C De Mello; T Morales
Journal: Experientia Date: 1964-03-15

8. The genetics of Caenorhabditis elegans.

Authors: S Brenner
Journal: Genetics Date: 1974-05 Impact factor: 4.562

9. Avermectins, new family of potent anthelmintic agents: efficacy of the B1a component.

Authors: J R Egerton; D A Ostlind; L S Blair; C H Eary; D Suhayda; S Cifelli; R F Riek; W C Campbell
Journal: Antimicrob Agents Chemother Date: 1979-03 Impact factor: 5.191

10. Avermectins, new family of potent anthelmintic agents: producing organism and fermentation.

Authors: R W Burg; B M Miller; E E Baker; J Birnbaum; S A Currie; R Hartman; Y L Kong; R L Monaghan; G Olson; I Putter; J B Tunac; H Wallick; E O Stapley; R Oiwa; S Omura
Journal: Antimicrob Agents Chemother Date: 1979-03 Impact factor: 5.191

23 in total

Review 1. Nematode cys-loop GABA receptors: biological function, pharmacology and sites of action for anthelmintics.

Authors: Michael V Accardi; Robin N Beech; Sean G Forrester
Journal: Invert Neurosci Date: 2012-03-20

2. Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi.

Authors: Yovany Moreno; Joseph F Nabhan; Jonathan Solomon; Charles D Mackenzie; Timothy G Geary
Journal: Proc Natl Acad Sci U S A Date: 2010-11-01 Impact factor: 11.205

3. A review of the pharmacology and clinical uses of ivermectin.

Authors: T B Barragry
Journal: Can Vet J Date: 1987-08 Impact factor: 1.008

Review 4. How do the macrocyclic lactones kill filarial nematode larvae?

Authors: Adrian J Wolstenholme; Mary J Maclean; Ruby Coates; Ciaran J McCoy; Barbara J Reaves
Journal: Invert Neurosci Date: 2016-06-09

Review 5. Ion channels and receptor as targets for the control of parasitic nematodes.

Authors: Adrian J Wolstenholme
Journal: Int J Parasitol Drugs Drug Resist Date: 2011-10-14 Impact factor: 4.077

6. On the mode of action of emodepside: slow effects on membrane potential and voltage-activated currents in Ascaris suum.

Authors: S K Buxton; C Neveu; C L Charvet; A P Robertson; R J Martin
Journal: Br J Pharmacol Date: 2011-09 Impact factor: 8.739