| Literature DB >> 6253045 |
Abstract
A melanin- and serotonin-producing bronchial carcinoid tumor is described. Melanin synthesis by neoplastic cells also containing electron-dense core (neurosecretory granules was documented by electron microscopy and serotonin content was found by biochemical assay to be 201.2 micrograms/g wet weight of tissue. Simultaneous demonstration of "endocrine" properties with characteristics of a cell of neural-crest origin provides strongly confirmatory evidence for the APUD cell theory of Pearse and makes an interesting commentary in regard to general theories of neoplasia.Entities:
Mesh:
Substances:
Year: 1980 PMID: 6253045 DOI: 10.1002/1097-0142(19801015)46:8<1843::aid-cncr2820460823>3.0.co;2-c
Source DB: PubMed Journal: Cancer ISSN: 0008-543X Impact factor: 6.860