Literature DB >> 6252864

Efficacy of a nucleic acid free herpetic subunit vaccine.

R Cappel, F de Cuyper, F Rickaert.   

Abstract

The efficacy of immunization with an herpes simplex subunit vaccine, free of nucleic acid, was evaluated in mice, rabbits and monkeys. One injection of 3 micrograms per kg of body weight elicited both humoral and cell-mediated immunity in all the animals studied. Furthermore, the immunization reduced significantly the mortality to a subsequent challenge with live herpes simplex virus in mice and rabbits (p less than 0.01).

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Year:  1980        PMID： 6252864     DOI： 10.1007/bf01340536

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  9 in total

1.  The Epstein-Barr virus and neoplasia.

Authors:  G Klein
Journal:  N Engl J Med       Date:  1975-12-25       Impact factor: 91.245

2.  Experimental immunosuppression induced by herpes simplex virus.

Authors:  R Cappel; C Henry; L Thiry
Journal:  Arch Virol       Date:  1975       Impact factor: 2.574

3.  Herpes simplex virus vaccines.

Authors:  T G Wise; P R Pavan; F A Ennis
Journal:  J Infect Dis       Date:  1977-11       Impact factor: 5.226

4.  Antibody and cell-mediated immunity to a DNA free herpes simplex subunit vaccine.

Authors:  R Cappel; F de Cuyper; J de Braekeleer
Journal:  Dev Biol Stand       Date:  1979

5.  Comparison of the humoral and cellular immune response after immunization with live, UV inactivated herpes simplex virus and a subunit vaccine and efficacy of these immunizations.

Authors:  R Cappel
Journal:  Arch Virol       Date:  1976       Impact factor: 2.574

Review 6.  The causative role of herpesvirus type 2 in cervical cancer.

Authors:  J L Melnick; E Adam; W E Rawls
Journal:  Cancer       Date:  1974-10       Impact factor: 6.860

7.  Analysis of bacteriophage T7 early RNAs and proteins on slab gels.

Authors:  F W Studier
Journal:  J Mol Biol       Date:  1973-09-15       Impact factor: 5.469

8.  Herpes simplex vaccines.

Authors:  M R Hilleman
Journal:  Cancer Res       Date:  1976-02       Impact factor: 12.701

9.  Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine.

Authors:  E N Kitces; P S Morahan; J G Tew; B K Murray
Journal:  Infect Immun       Date:  1977-06       Impact factor: 3.441
  9 in total
  10 in total

Review 1.  Herpes simplex viruses: is a vaccine tenable?

Authors:  Richard J Whitley; Bernard Roizman
Journal:  J Clin Invest       Date:  2002-07       Impact factor: 14.808

Review 2.  The pathogenesis of acute, latent and recurrent herpes simplex virus infections.

Authors:  R J Klein
Journal:  Arch Virol       Date:  1982       Impact factor: 2.574

3.  The influence of different modes of immunization on the experimental genital herpes simplex virus infection of mice.

Authors:  K E Schneweis; J Gruber; J Hilfenhaus; A Möslein; M Kayser; M H Wolff
Journal:  Med Microbiol Immunol       Date:  1981       Impact factor: 3.402

4.  Latent HSV-1 infection in mice immunized with a zwitterionic detergent-extracted HSV-1 antigen preparation.

Authors:  A al-Ghamdi; R Jennings; H Bentley; C W Potter
Journal:  Arch Virol       Date:  1989       Impact factor: 2.574

5.  Animal studies on the efficacy of vaccination against recurrent herpes.

Authors:  M Scriba
Journal:  Med Microbiol Immunol       Date:  1982       Impact factor: 3.402

6.  Immune response to a DNA free herpes simplex vaccine in man.

Authors:  R Cappel; S Sprecher; F Rickaert; F de Cuyper
Journal:  Arch Virol       Date:  1982       Impact factor: 2.574

7.  Zwitterionic detergent solubilisation of HSV-1 surface antigens.

Authors:  R Jennings; T Quasim; R M Sharrard; D Hockley; C W Potter
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

8.  Comparison of effects of adjuvants on efficacy of virion envelope herpes simplex virus vaccine against labial infection of BALB/c mice.

Authors:  T A Thomson; J Hilfenhaus; H Moser; P S Morahan
Journal:  Infect Immun       Date:  1983-08       Impact factor: 3.441

9.  Protectivity of herpes simplex virus antigens: studies in mice on the adjuvant effect of PICLC and on the dependence of protection on T cell competence.

Authors:  J Hilfenhaus; H Christ; R Köhler; H Moser; H Kirchner; H B Levy
Journal:  Med Microbiol Immunol       Date:  1981       Impact factor: 3.402

10.  Efficacy of a virion envelope herpes simplex virus vaccine against experimental skin infections in hairless mice.

Authors:  R J Klein; E Buimovici-Klein; H Moser; R Moucha; J Hilfenhaus
Journal:  Arch Virol       Date:  1981       Impact factor: 2.574
  10 in total

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